{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:56:09Z","timestamp":1789916169301,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study long\u2010term sequelae in children with Guillain\u2013Barr\u00e9 syndrome (GBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective observational study with children from two French tertiary centres. Data were from clinical and several standardized scales or questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients were included with a median follow\u2010up of 6\u2009years 4\u2009months (range 3\u201320\u2009years) after the acute phase. The sequelae rate was 67% (95% confidence interval [CI]\u200953\u201378) and did not vary with time. Most children had minor sequelae (Guillain\u2013Barr\u00e9 Syndrome Disability Score [GBSDS]\u2009=\u20091); only one was unable to run (GBSDS\u2009=\u20092). The most frequent complaints were paraesthesia (43%), pain (35%), and fatigue (31%). The neurological examination was abnormal in 18% of children, autonomy was compromised in 14%, and symptoms of depression occurred in 34%. The factors associated with late\u2010onset sequelae were correlated with severity during the initial phase (i.e. initial GBSDS\u2009&gt;4, odds ratio 6.6, 95% CI 1.8\u201333; <jats:italic>p<\/jats:italic>\u2009=\u20090.009). The predictive factors of more severe late\u2010onset conditions were initial severity (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and sex (female patients; <jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Two\u2010thirds of children with GBS had late\u2010onset sequelae following an episode, often minor, but sometimes with continuing effects on their everyday lives. Particularly affected were those who had severe GBS during the acute phase and who lost the ability to walk.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Two\u2010thirds of children with Guillain\u2013Barr\u00e9 syndrome (GBS) had persistent sequelae.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sequelae were often minor, but daily repercussions of them were sometimes serious.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sequelae were significantly associated with severe GBS during the acute phase.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15693","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T04:18:41Z","timestamp":1690517921000},"page":"176-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term outcomes 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