{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:06:02Z","timestamp":1787846762582,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To quantify the cervicomedullary motor evoked potentials (CMEPs) at the cervical spinal level in adults with cerebral palsy (CP) and determine if altered CMEPs are linked with upper\u2010extremity motor function in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This cross\u2010sectional study consisted of a cohort of adults with CP (<jats:italic>n<\/jats:italic>\u2009=\u200915; mean age\u2009=\u200933\u2009years 5\u2009months [SD\u2009=\u200911\u2009years 8\u2009months]); Manual Ability Classification System levels I\u2013IV) and neurotypical controls (<jats:italic>n<\/jats:italic>\u2009=\u200918; mean age\u2009=\u200930\u2009years 10\u2009months [SD\u2009=\u200910\u2009years 4\u2009months]), who were recruited to participate at an academic medical center. Adults with CP and typical adults (controls) were stimulated at the cervicomedullary junction to assess CMEPs at the cervical spinal cord level. Upper\u2010extremity motor function was quantified using the Box and Blocks and Purdue Pegboard tests, self\u2010reported upper\u2010extremity function (UEF), and assessments of selective motor control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At higher stimulation levels, the contralateral CMEP responses of adults with CP were different from typical adults (<jats:italic>p<\/jats:italic>\u2009=\u20090.032). Reduced CMEP was correlated with reduced upper\u2010limb function, including worse performance on the Box and Blocks (rho\u2009=\u20090.625, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and Purdue Pegboard tests (rho\u2009=\u20090.701, <jats:italic>p<\/jats:italic>\u2009=\u20090.010), lower self\u2010reported UEF (rho\u2009=\u20090.761, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), and overall selective motor control (rho\u2009=\u20090.731, <jats:italic>p<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Changes in the activation of spinal motoneurons through corticospinal pathways may have an important role in the altered upper\u2010extremity motor function of individuals with CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15750","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:17:06Z","timestamp":1694150226000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Linking corticospinal tract activation and upper\u2010limb motor control in adults with cerebral palsy"],"prefix":"10.1111","volume":"66","author":[{"given":"Saihari S.","family":"Dukkipati","sequence":"first","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Trevarrow","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan T.","family":"Busboom","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Schlieker","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-5474","authenticated-orcid":false,"given":"Max J.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha NE USA"},{"name":"Department of Pharmacology &amp; 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