{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:46:41Z","timestamp":1767340001321,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG LI1925\/4\u20101"],"award-info":[{"award-number":["DFG LI1925\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess how atypical language organization after early left\u2010hemispheric brain lesions affects grey matter in the contralesional hemisphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a cross\u2010sectional study with between\u2010group comparisons of 14 patients (six female, 8\u201326\u2009years) with perinatal left\u2010hemispheric brain lesions (two arterial ischemic strokes, 11 periventricular haemorrhagic infarctions, one without classification) and 14 typically developing age\u2010matched controls (TDC) with functional magnetic resonance imaging (fMRI) documented left\u2010hemispheric language organization (six female, 8\u201328\u2009years). MRI data were analysed with SPM12, CAT12, and custom scripts. Language lateralization indices were determined by fMRI within a prefrontal mask and right\u2010hemispheric grey matter group differences by voxel\u2010based morphometry (VBM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FMRI revealed left\u2010dominance in seven patients with typical language organization (TYP) and right\u2010dominance in seven patients with atypical language organization (ATYP) of 14 patients. VBM analysis of all patients versus controls showed grey matter reductions in the middle temporal gyrus of patients. A comparison between the two patient subgroups revealed an increase of grey matter in the middle frontal gyrus in the ATYP group. Voxel\u2010based regression analysis confirmed that grey matter increases in the middle frontal gyrus were correlated with atypical language organization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Compatible with a non\u2010specific lesion effect, we found areas of grey matter reduction in patients as compared to TDC. The grey matter increase in the middle frontal gyrus seems to reflect a specific compensatory effect in patients with atypical language organization.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Perinatal stroke leads to decreased grey matter in the contralesional hemisphere.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Atypical language organization is associated with grey matter increases in contralesional language areas.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15751","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T06:29:39Z","timestamp":1694413779000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Atypical language organization following perinatal infarctions of the left hemisphere is associated with 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