{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:09Z","timestamp":1787014089140,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000311","name":"Tuberous Sclerosis Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To characterize early changes in developmental ability, language, and adaptive behaviour in infants diagnosed with tuberous sclerosis complex (TSC), and determine whether clinical features of epilepsy influence this pathway.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Prospective, longitudinal data were collected within the Early Development in Tuberous Sclerosis (EDiTS) Study to track development of infants with TSC (\n n<\/jats:italic>\n \u2009=\u200932) and typically developing infants (\n n<\/jats:italic>\n \u2009=\u200933) between 3 and 24\u2009months of age. Questionnaire and observational measures were used at up to seven timepoints to assess infants' adaptive behaviour, developmental ability, language, and epilepsy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A significant group by age interaction effect showed that infants with TSC had lower adaptive functioning at 18 to 24\u2009months old (intercept\u2009=\u200988.12, slope estimate\u2009=\u2009\u22120.82,\n p<\/jats:italic>\n \u2009<\u20090.001) and lower developmental ability scores from 10\u2009months old (intercept\u2009=\u200983.33, slope estimate\u2009=\u2009\u22121.44,\n p<\/jats:italic>\n \u2009<\u20090.001) compared to typically developing infants. Early epilepsy severity was a significant predictor of these emerging developmental (\n R<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20090.35,\n p<\/jats:italic>\n \u2009=\u20090.004, 95% confidence interval [CI] \u20130.08 to \u22120.01) and adaptive behaviour delays\n (R<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20090.34,\n p<\/jats:italic>\n \u2009=\u20090.004, 95% CI \u20130.05 to \u22120.01]). Lower vocabulary production (intercept\u2009=\u2009\u22121.25, slope\u2009=\u2009\u22120.12,\n p<\/jats:italic>\n \u2009<\u20090.001) and comprehension scores (intercept\u2009=\u20092.39, slope estimate\u2009=\u2009\u22120.05,\n p<\/jats:italic>\n \u2009<\u20090.001) in infants with TSC at 24\u2009months old were not associated with epilepsy severity.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n Divergence of developmental ability and adaptive functioning skills occur in infants with TSC from 10 and 18\u2009months, respectively. Associations between early epilepsy severity and impaired development supports the importance of early intervention to reduce seizure severity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dmcn.15765","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:50:03Z","timestamp":1698367803000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early development and epilepsy in tuberous sclerosis complex: A\u00a0prospective longitudinal study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-6890","authenticated-orcid":false,"given":"Natasha","family":"Lindsay","sequence":"first","affiliation":[{"name":"Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Runicles","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Cambridge Cambridge UK"},{"name":"Centre for Brain & Cognitive Development, Birkbeck University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J. 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