{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T15:30:05Z","timestamp":1749569405738,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare growth in individuals with cyclin\u2010dependent kinase\u2010like 5 (CDKL5) deficiency disorder with population norms and to investigate the effect of gastrostomy on growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The longitudinal study included 353 individuals from the International CDKL5 Disorder Database with any anthropometric measurement in baseline and\/or follow\u2010up questionnaires. The British 1990 growth reference was used to determine the age\u2010 and sex\u2010standardized z\u2010score. Repeated cross\u2010sectional data were fitted using a Gaussian linear regression model with generalized estimating equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All growth parameters were below the general population norm (mean z\u2010scores: weight\u2009\u22120.97, height\u2009\u22120.65, body mass index [BMI] \u22120.81, head circumference\u2009\u22122.12). The disparity was particularly pronounced for all anthropometric measurements after 4\u2009years of age except for BMI. Moreover, individuals with gastrostomy placement were shown to have a larger decrease than those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In addition to weight, height, and BMI, head circumference was also compromised in this disorder. Microcephaly could be considered a helpful diagnostic feature, especially in adults. Any benefit of gastrostomy on weight and BMI was mainly seen in the early years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15777","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:42:19Z","timestamp":1696668139000},"page":"469-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Growth patterns in individuals with <scp>CDKL5<\/scp> deficiency disorder"],"prefix":"10.1111","volume":"66","author":[{"given":"Kingsley","family":"Wong","sequence":"first","affiliation":[{"name":"Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University Hospitals Bristol and Weston  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-5834","authenticated-orcid":false,"given":"Helen","family":"Leonard","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-9037","authenticated-orcid":false,"given":"Jenny","family":"Downs","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Junaid","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-2529","authenticated-orcid":false,"given":"Sam","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University Hospitals Bristol and Weston  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00035-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz195"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/426462"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/426460"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13862"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0418-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.156"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738211019284"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6956934"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.874695"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3304-x"},{"issue":"131","key":"e_1_2_10_14_1","article-title":"Risk of Hospitalizations Following Gastrostomy in Children with Intellectual Disability","volume":"217","author":"Jacoby P","year":"2020","journal-title":"J Pediatr"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12729"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315629"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.09.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0563-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826e9a70"},{"issue":"188","key":"e_1_2_10_20_1","article-title":"Impact of Gastrostomy Placement on Nutritional Status, Physical Health, and Parental Well\u2010Being of Females with Rett Syndrome: A Longitudinal Study of an Australian Population","volume":"200","author":"Wong K","year":"2018","journal-title":"J Pediatr"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-022-01163-1"},{"key":"e_1_2_10_23_1","first-page":"1","article-title":"CDC growth charts: United States. 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