{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:45:27Z","timestamp":1789623927890,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate functional motor performance in a large cohort of young steroid\u2010na\u00efve males with Duchenne muscular dystrophy (DMD) and typically developing males, and to develop specific reference curves for both groups. Also, to describe associations between anthropometric values and functional motor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Cross\u2010sectional data of 196 steroid\u2010na\u00efve males with DMD aged 4 to 8\u2009years and 497 typically developing males aged 2\u2009years 6\u2009months to 8\u2009years were included. Both groups were evaluated with the time to rise from the floor test, 10\u2010metre walk\/run test, 6\u2010minute walk test, and North Star Ambulatory Assessment. Reference curves with centiles 5%, 10%, 25%, 50%, 75%, 90%, and 95% were estimated using quantile regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Males with DMD scored significantly worse on all functional motor outcomes than age\u2010matched typically developing males (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001): 89% to 95% of the males with DMD scored below the 5th centile of the typically developing males. No or weak correlations exist between anthropometric values and functional motor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The estimated reference curves can support consultation with families of young males with DMD and can support the evaluation of treatment for reaching motor skills and functional motor outcomes compared with typically developing males.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15788","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:28:54Z","timestamp":1698373734000},"page":"644-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reference curves of motor function outcomes in young steroid\u2010na\u00efve males with Duchenne muscular dystrophy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-1810","authenticated-orcid":false,"given":"Jasmine","family":"Hoskens","sequence":"first","affiliation":[{"name":"Faculty of Rehabilitation Sciences Rehabilitation Research Center (REVAL), UHasselt  Leuven Belgium"},{"name":"Department of Rehabilitation Sciences Research Group for Neurorehabilitation (eNRGy), KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianela","family":"Schiava","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Goemans","sequence":"additional","affiliation":[{"name":"Department of Child Neurology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Feys","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Research Group for Neurorehabilitation (eNRGy), KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"},{"name":"Department of Biostatistics and Computational Biology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mayhew","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrijn","family":"Klingels","sequence":"additional","affiliation":[{"name":"Faculty of Rehabilitation Sciences Rehabilitation Research Center (REVAL), UHasselt  Leuven Belgium"},{"name":"Department of Rehabilitation Sciences Research Group for Neurorehabilitation (eNRGy), KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Guglieri","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2004.01.009"},{"key":"e_1_2_10_4_1","first-page":"453","volume":"8","author":"Norcia G","year":"2021","journal-title":"Early Gross Motor Milestones in Duchenne Muscular Dystrophy."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21808"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225ab2e"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Long\u2010term natural history data in Duchenne muscular dystrophy ambulant patients with mutations amenable to skip exons 44, 45, 51 and 53","author":"Brogna C","year":"2019","journal-title":"PLoS 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