{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:16Z","timestamp":1791309856031,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008588","name":"Stiftelsen Sunnerdahls Handikappfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009389","name":"Stiftelsen Promobilia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009389","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n The aim of this observational study was to determine the immune status and function in young adults with cerebral palsy (CP) in comparison to typically developing individuals.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Blood samples from 12 individuals with CP (five males, seven females; mean age: 25\u2009years 1\u2009month (5\u2009years 9\u2009months); age range: 19\u201338\u2009years) and 17 typically developing individuals (eight males, nine females; mean age: 31\u2009years 4\u2009months (6\u2009years 2\u2009months); age range: 20\u201340\u2009years) were collected before, immediately after, and 1\u2009hour after 45\u2009minutes of frame running or running respectively. Independent\n t<\/jats:italic>\n \u2010tests were used to compare heart rate, level of exertion, and baseline cell proportions between groups. Mixed model analysis of variance was utilized to investigate immune cell responses to exercise across groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline levels of gamma delta (TCR\u03b3\u03b4+) T\u2010cells were significantly higher (absolute percentage: +2.65,\n p<\/jats:italic>\n \u2009=\u20090.028) in the individuals with CP. Several cell populations showed similar significant changes after exercise in both CP and typically developing groups. Cytotoxic (CD8+) T\u2010cells were only significantly elevated immediately after exercise in the typically developing participants (\n p<\/jats:italic>\n \u2009<\u20090.01). Individuals with CP exhibited significantly lower heart rates (\u221211.1%,\n p<\/jats:italic>\n \u2009<\u20090.01), despite similar ratings of perceived exertion.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n Elevated baseline TCR\u03b3\u03b4+ T\u2010cells may indicate low\u2010grade inflammation in adults with CP. Although most of the cell populations showed typical responses to endurance exercise, the absence of response in CD8+ T\u2010cells in individuals with CP may indicate the need for higher intensity during exercise.<\/jats:p>\n <\/jats:sec>\n \n What this paper adds<\/jats:title>\n \n \n \n TCR\u03b3\u03b4+ T\u2010cell baseline levels are elevated in adults with cerebral palsy (CP).<\/jats:p>\n <\/jats:list-item>\n \n The CD8+ T\u2010cell response to exercise was blunted in adults with CP.<\/jats:p>\n <\/jats:list-item>\n \n Exercise intensity is decisive for CD8+ T\u2010cell responses in individuals with CP.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dmcn.15835","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T04:12:42Z","timestamp":1702959162000},"page":"902-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating immune cell populations at rest and in response to acute endurance exercise in young adults with cerebral palsy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-1253","authenticated-orcid":false,"given":"Annika","family":"Kruse","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health, Division of Neurology\/Pediatric Orthopedics Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"},{"name":"Institute of Human Movement Science, Sport and Health University of Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Imery","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Neurology\/Pediatric Orthopedics Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"},{"name":"College of Health and Human Performance University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn\u00e9a","family":"Corell","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Neurology\/Pediatric Orthopedics Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-5209","authenticated-orcid":false,"given":"Emma","family":"Hjalmarsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Neurology\/Pediatric Orthopedics Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"},{"name":"Functional Area Occupational Therapy and Physiotherapy Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-9855","authenticated-orcid":false,"given":"Rodrigo","family":"Fernandez\u2010Gonzalo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Physiology Karolinska Institutet Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-2252","authenticated-orcid":false,"given":"Ferdinand","family":"Von\u00a0Walden","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Neurology\/Pediatric Orthopedics Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-2780","authenticated-orcid":false,"given":"Stefan M.","family":"Reitzner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.82"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.620852"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-11-49"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001559"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1999.tb00660.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351295"},{"key":"e_1_2_9_8_1","first-page":"6","article-title":"Position statement. 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