{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:39:18Z","timestamp":1789151958853,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022221","name":"Sickkids Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine whether antenatal diagnosis modifies relationships between neonatal brain volumes and 18\u2010month neurodevelopmental outcomes in children with transposition of the great arteries (TGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a retrospective cohort of 139 children with TGA (77 antenatally diagnosed), we obtained total brain volumes (TBVs) on pre\u2010 (<jats:italic>n<\/jats:italic>\u2009=\u2009102) and postoperative (<jats:italic>n<\/jats:italic>\u2009=\u2009112) magnetic resonance imaging. Eighteen\u2010month neurodevelopmental outcomes were assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. Generalized estimating equations with interaction terms were used to determine whether antenatal diagnosis modified associations between TBVs and neurodevelopmental outcomes accounting for postmenstrual age at scan, brain injury, and ventricular septal defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants with postnatal diagnosis had more preoperative hypotension (35% vs 14%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). The interactions between antenatal diagnosis and TBVs were significantly related to cognitive (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) outcomes. Specifically, smaller TBVs were associated with lower cognitive scores in infants diagnosed postnatally; this association was attenuated in those diagnosed antenatally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Antenatal diagnosis modifies associations between neonatal brain volume and 18\u2010month cognitive outcome in infants with TGA. These findings suggest that antenatal diagnosis may be neuroprotective, possibly through improved preoperative clinical status. These data highlight the need to improve antenatal diagnosis rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Antenatal diagnosis of transposition of the great arteries modified relationships between neonatal brain volume and neurodevelopment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Smaller brain volumes related to poorer cognitive scores with postnatal diagnosis only.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>There was more preoperative hypotension in the postnatal diagnosis group.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15840","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:10:18Z","timestamp":1704960618000},"page":"882-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antenatal diagnosis, neonatal brain volumes, and neurodevelopment in transposition of the great arteries"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-2434","authenticated-orcid":false,"given":"Thiviya","family":"Selvanathan","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto ON Canada"},{"name":"Department of Pediatrics BC Children's Hospital Research Institute and the University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Mabbott","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health The Hospital for Sick Children Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie H.","family":"Au\u2010Young","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto ON Canada"},{"name":"Neurosciences and Mental Health The Hospital for Sick Children Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Seed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto ON Canada"},{"name":"Heart Centre The Hospital for Sick Children  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto ON Canada"},{"name":"Department of Pediatrics BC Children's Hospital Research Institute and the University of British Columbia  Vancouver BC Canada"},{"name":"Neurosciences and Mental Health The Hospital for Sick Children Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vann","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto ON Canada"},{"name":"Neurosciences and Mental Health The Hospital for Sick Children Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PCNR Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-016-0016-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-20-267"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.01.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1995-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1277"},{"issue":"94","key":"e_1_2_11_7_1","article-title":"Impact of prenatal diagnosis on neurocognitive outcomes in children with transposition of the great arteries","volume":"161","author":"Calderon J","year":"2012","journal-title":"J Pediatr"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.e335"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4450"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037495"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000751"},{"key":"e_1_2_11_12_1","unstructured":"MathesonF MoloneyG vanIngenT Ontario Agency for Health Protection and Promotion P. 2016 Ontario marginalization index: user guide. 1st revision. 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