{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:45:28Z","timestamp":1779399928628,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the efficacy of intravenous clonazepam (CLZ) for the initial management of convulsive status epilepticus (CSE) in children as a function of the first\u2010line in\u2010hospital dose used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This monocentric retrospective study included children who received a first dose of CLZ for CSE at Montpellier University Hospital, France, between January 2016 and June 2019. Data from medical records (clinical, treatment, course) were collected and compared as a function of the first CLZ dose used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 310 children treated for CSE, 105 received at least one CLZ dose (median age 3\u2009years; quartile 1\u2013quartile 3 [Q1\u2013Q3]\u2009=\u20091\u2009years 2\u2009months\u20136\u2009years 6\u2009months). Among these 105 patients, 24 (22%) received a dose less than 0.03\u2009mg\/kg (low dose) and 69 (65%) received a dose of at least 0.03\u2009mg\/kg (high dose). Seizure cessation rate was not different between the low\u2010 and high\u2010dose groups (62.5% vs 76%; odds ratio 0.53, 95% confidence interval [CI] 0.19\u20131.44, <jats:italic>p<\/jats:italic>\u2009=\u20090.29). The administration of a second dose of CLZ was more frequent in the low\u2010 than the high\u2010dose group (37.5% vs 16%; odds ratio 3.2, 95% CI 1.1\u20139.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our study did not find any difference in seizure termination rate as a function of CLZ dose in children with CSE. However, a second CLZ dose was more frequently needed in the group receiving low (less than 0.03\u2009mg\/kg) CLZ.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15859","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T06:35:00Z","timestamp":1706078100000},"page":"1053-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of intravenous clonazepam for paediatric convulsive status epilepticus"],"prefix":"10.1111","volume":"66","author":[{"given":"Maxime","family":"Colmard","sequence":"first","affiliation":[{"name":"D\u00e9partement de Neurop\u00e9diatrie CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rivier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurop\u00e9diatrie CHU de Montpellier  Montpellier France"},{"name":"PhyMedExp, CNRS, INSERM Universit\u00e9 de 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