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FXS is the leading cause of inherited intellectual disabilities and the most commonly known genetic cause of autism spectrum disorder. Children with FXS experience behavioral and sleep problems, anxiety, inattention, learning difficulties, and speech and language delays. There are no approved medications for FXS; however, there are several interventions and treatments aimed at managing the symptoms and improving the quality of life of individuals with FXS. A combination of non\u2010pharmacological therapies and pharmacotherapy is currently the most effective treatment for FXS. Currently, several targeted treatments, such as metformin, sertraline, and cannabidiol, can be used by clinicians to treat FXS. Gene therapy is rapidly developing and holds potential as a prospective treatment option. Soon its efficacy and safety in patients with FXS will be demonstrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Targeted treatment of fragile X syndrome (FXS) is the best current therapeutic approach.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Gene therapy holds potential as a prospective treatment for FXS in the future.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15885","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T15:24:47Z","timestamp":1708615487000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["State\u2010of\u2010the\u2010art therapies for fragile X syndrome"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-5405","authenticated-orcid":false,"given":"Dragana","family":"Protic","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Fragile X Clinic, Special Hospital for Cerebral Palsy and Developmental Neurology  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-8448","authenticated-orcid":false,"given":"Randi","family":"Hagerman","sequence":"additional","affiliation":[{"name":"Medical Investigation of Neurodevelopmental Disorders Institute University of California  Davis CA USA"},{"name":"Department of Pediatrics, University of California, Davis School of Medicine  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.6.809"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1126"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990402)83:4<248::AID-AJMG3>3.0.CO;2-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5395"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-05-01539.1997"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2563"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9050096"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2302534120"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm401"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226811"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23041935"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104740"},{"key":"e_1_2_11_16_1","volume-title":"Fragile X Syndrome and Premutation Disorders","author":"Hagerman RJ","year":"2020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1044\/0161-1461(2003\/026)"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1159F"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2012.01608.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.15280\/jlm.2015.5.2.35"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000289116"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.3\/akaczkurkin"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2014.01026"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-010-9067-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.12.2008"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.12.015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CP05771J"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000334"},{"key":"e_1_2_11_29_1","article-title":"Review of Autism Profiles and Response to Sertraline in Fragile X Syndrome\u2010Associated Autism vs","volume":"11","author":"Rajaratnam A","year":"2020","journal-title":"Non\u2010syndromic Autism; Next Steps for Targeted Treatment. 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