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Dystonia can interfere with activities and have considerable impact on motor function, pain\/comfort, and ease of caregiving. Although pharmacological and neurosurgical approaches are used clinically in individuals with CP and dystonia that is causing interference, evidence to support these options is limited. This clinical practice guideline update comprises 10 evidence\u2010based recommendations on the use of pharmacological and neurosurgical interventions for individuals with CP and dystonia causing interference, developed by an international expert panel following the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The recommendations are intended to help inform clinicians in their use of these management options for individuals with CP and dystonia, and to guide a shared decision\u2010making process in selecting a management approach that is aligned with the individual's and the family's values and preferences.<\/jats:p>","DOI":"10.1111\/dmcn.15921","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:10:04Z","timestamp":1713532204000},"page":"1133-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-1028","authenticated-orcid":false,"given":"Darcy","family":"Fehlings","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-5908","authenticated-orcid":false,"given":"Brenda","family":"Agnew","sequence":"additional","affiliation":[{"name":"Family Advisor AACPDM, CP\u2010NET  Burlington Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-6415","authenticated-orcid":false,"given":"Hortensia","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Barts NHS Health and Queen Mary University of London, Wolfson Institute of Population Health Centre for Preventive Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-7382","authenticated-orcid":false,"given":"Adrienne","family":"Harvey","sequence":"additional","affiliation":[{"name":"Neurodisability and Rehabilitation Murdoch Children's Research Institute  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-9554","authenticated-orcid":false,"given":"Kate","family":"Himmelmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences &amp; Medicine, King's Health Partners Complex Motor Disorders Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Women's and Children's Health Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Mink","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elegast","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Technology Lab KU Leuven Campus Brugge  Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-4642","authenticated-orcid":false,"given":"James","family":"Rice","sequence":"additional","affiliation":[{"name":"Paediatric Rehabilitation Department Women's and Children's Hospital  North Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-0228","authenticated-orcid":false,"given":"Emma","family":"Bohn","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngve","family":"Falck\u2010Ytter","sequence":"additional","affiliation":[{"name":"Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e89"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03483.x"},{"key":"e_1_2_12_5_1","unstructured":"National Institute of Neurological Disorders and Stroke.Dystonia Bethesda MD: National Institute of Neurological Disorders and Stroke; [updated 2023 Jan 20; cited 2023 Feb 1]. 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