{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:15:59Z","timestamp":1783919759615,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment, Government of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the validity of the Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations\u2013Questionnaire (ESSENCE\u2010Q), a simple screening tool for neurodevelopmental problems, in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Parents\/caregivers completed the 11\u2010item ESSENCE\u2010Q for 77\u2009612 children aged 2\u2009years 6\u2009months included in a national birth cohort study. Information about neurodevelopmental disorders (NDDs: autism spectrum disorder; intellectual disability and\/or developmental language disorder; motor delay\/motor disorder) was collected at age 3\u2009years. Each ESSENCE\u2010Q item was scored on a binary (0,1) scale, with a total score range of 0 to 11. Total scores and individual items were compared across children with and without NDDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NDDs were recorded in 854 children (1.1%). With a total ESSENCE\u2010Q score cut\u2010off of \u22653, receiver operating characteristic curve analysis showed an area under the curve of 0.91, with sensitivity 84.9%, specificity 84.8%, positive predictive value 5.9%, and negative predictive value 99.8%. The proportion of parental concerns at 2\u2009years 6\u2009months differed significantly by NDD status for communication (89.5% vs 14.2%) and general development (80.2% vs 7.4%). ESSENCE\u2010Q total scores were moderately negatively correlated (\u22120.36, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with Japanese Ages and Stages Questionnaire scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The parent\/caregiver\u2010completed ESSENCE\u2010Q is useful as a tool for screening out children with neurotypical development at this early age. Further research into longer\u2010term predictive validity will be possible as more NDD diagnoses are given as the children grow up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15956","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T06:28:35Z","timestamp":1716013715000},"page":"1611-1621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validity of the <scp>ESSENCE\u2010Q<\/scp> neurodevelopmental screening tool in Japan"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-3514","authenticated-orcid":false,"given":"Kahoko","family":"Yasumitsu\u2010Lovell","sequence":"first","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Kochi Gillberg Neuropsychiatry Centre  Kochi Japan"},{"name":"Department of Environmental Medicine, Kochi Medical School Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-3262","authenticated-orcid":false,"given":"Lucy","family":"Thompson","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Institute of Applied Health Sciences University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-7747","authenticated-orcid":false,"given":"Elisabeth","family":"Fernell","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-9670","authenticated-orcid":false,"given":"Masamitsu","family":"Eitoku","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Kochi Medical School Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-6216","authenticated-orcid":false,"given":"Narufumi","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Kochi Medical School Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-1934","authenticated-orcid":false,"given":"Christopher","family":"Gillberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Kochi Gillberg Neuropsychiatry Centre  Kochi Japan"},{"name":"Department of Environmental Medicine, Kochi Medical School Kochi University  Kochi Japan"},{"name":"School of Health and Wellbeing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Japan Environment and Children's Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.06.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30376-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2020.22.1\/macrocq"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13050"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1115834"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S108411"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.08.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15835"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S132546"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S171359"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15029"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2022.103162"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-05080-y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S374930"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S367196"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13990"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-25"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20170018"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140186"},{"issue":"7","key":"e_1_2_11_21_1","first-page":"761","article-title":"[Formula: see text]Selecting measures for the neurodevelopmental assessment of children in low\u2010 and middle\u2010income countries","volume":"23","author":"Semrud\u2010Clikeman M","year":"2017","journal-title":"Child Neuropsychol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec173d"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7458.168"},{"key":"e_1_2_11_24_1","volume-title":"Diagnostic Testing Accuracy: Sensitivity, Specificity, Predictive Values and Likelihood Ratios","author":"Shreffler J","year":"2022"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02528-y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2009.01041.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2008.01388.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10597-021-00774-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2019.06.003"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.15956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:04:47Z","timestamp":1731920687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.15956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/dmcn.15956"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.15956","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]},"assertion":[{"value":"2023-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}