{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:35Z","timestamp":1787244335593,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019902","name":"Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","award":["Post doc position in the study"],"award-info":[{"award-number":["Post doc position in the study"]}],"id":[{"id":"10.13039\/100019902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effect of single botulinum neurotoxin A (BoNT\u2010A) injections\u00a0into the calf muscles on the gross energy cost of walking in children with cerebral palsy (CP) and to evaluate the effect of BoNT\u2010A on walking capacity, physical activity, perceived changes in mobility, and pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This was an industry\u2010independent, randomized, quadruple\u2010blind, placebo\u2010controlled, multicentre trial (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      registration: NCT02546999). Sixty\u2010one children (33 male, median age [range]\u2009=\u20098\u2009years [4\u201316\u2009years]) with spastic CP and classified in Gross Motor Function Classification System (GMFCS) levels I and II allocated to single injections of either BoNT\u2010A or 0.9% saline into the calf muscles. The main outcome was gross energy cost (J\/kg\/m); secondary outcomes were walking capacity, habitual physical activity, perceived change in mobility tasks, and calf pain at baseline, 4\u2009weeks (P1), 12\u2009weeks (P2), and 24\u2009weeks (P3) after the injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean change in energy cost did not differ significantly between groups at the primary time point P2 (\u22120.27\u2009J\/kg\/m, 95% confidence interval\u2009\u2212\u20090.91 to 0.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.404), nor at P1 or P3. Regarding the secondary outcomes, there was some evidence of a larger reduction in pain intensity in the group given BoNT\u2010A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>One treatment with BoNT\u2010A was not superior to placebo in making walking easier in children with CP classified in GMFCS levels I and II, at least in the short term. BoNT\u2010A may have a pain\u2010reducing effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.16038","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:43:04Z","timestamp":1722001384000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-1804","authenticated-orcid":false,"given":"Siri Merete","family":"Br\u00e6ndvik","sequence":"first","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology, NTNU  Trondheim Norway"},{"name":"Rehabilitation Clinic St. Olavs University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Elisabeth","family":"Ross Raftemo","sequence":"additional","affiliation":[{"name":"Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology, NTNU  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Roeleveld","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology, NTNU  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guro Lillemoen","family":"Andersen","sequence":"additional","affiliation":[{"name":"Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology, NTNU  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti","family":"Ramstad","sequence":"additional","affiliation":[{"name":"Oslo University Hospital  Oslo 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