{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T21:22:54Z","timestamp":1787088174580,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the role of parental magnetic resonance imaging (MRI) in assessing fetuses with suspected brain anomalies and its use in prenatal counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective, multicentre chart review was conducted on fetuses who underwent brain MRI because of suspected brain abnormalities between January 2008 and December 2022, with one or both parents who underwent brain MRI (MRI\u2010Trio) as part of prenatal counselling. Clinical and demographic data were collected, including fetal and parental MRI findings, prenatal counselling outcomes, genetic testing results, family and previous pregnancy history, neurological examinations of the born children up to 24\u2009months of age, and autopsy reports of fetuses from terminated pregnancies. MRI\u2010Trio concordance was defined as at least one abnormal brain feature identified with similarity in the fetus and the parents. The live\u2010born children were assessed postnatally through either neurodevelopmental evaluations or telephone interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty pregnancies were included (41.7% with concordant and 58.3% with discordant MRI\u2010Trio). Forty\u2010two children were born (70%) and 17 pregnancies were terminated (28.3%). One case of in utero fetal death (1.7%) was reported. The most common brain findings were multiple anomalies (<jats:italic>n<\/jats:italic>\u2009=\u200926, 43.3%), isolated disorders of the corpus callosum (<jats:italic>n<\/jats:italic>\u2009=\u200917, 28.3%), atypical periventricular pseudocysts (<jats:italic>n<\/jats:italic>\u2009=\u20096, 10%), and anomalies of the anterior complex (<jats:italic>n<\/jats:italic>\u2009=\u20094, 6.7%). MRI\u2010Trio enabled better prognostication. When MRI\u2010Trio was concordant, counselling was more favourable (<jats:italic>n<\/jats:italic>\u2009=\u200922, 36.6%) and the majority of live\u2010born children exhibited typical development (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>MRI\u2010Trio is a valuable tool for identifying dominantly inherited brain anomalies that may not hold developmental significance or are associated with favourable outcomes, acknowledging the potential for variable penetrance, which may result in more severe presentations. Concordant MRI\u2010Trio findings can enhance the accuracy of prenatal counselling, potentially reducing the incidence of termination of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.16071","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T14:28:32Z","timestamp":1726064912000},"page":"463-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Parental magnetic resonance imaging for the evaluation of fetuses with brain anomalies"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4706-1949","authenticated-orcid":false,"given":"Stephanie","family":"Libzon","sequence":"first","affiliation":[{"name":"Multidisciplinary Fetal Neurology Center, Wolfson Medical Center  Holon Israel"},{"name":"Department of Physical Therapy, School of Health Professions, Faculty of Medicine Tel\u00a0Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-7334","authenticated-orcid":false,"given":"Michal","family":"Gafner","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"},{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Lev","sequence":"additional","affiliation":[{"name":"Multidisciplinary Fetal Neurology Center, Wolfson Medical Center  Holon Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-8649","authenticated-orcid":false,"given":"Nilly","family":"Waiserberg","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, School of Health Professions, Faculty of Medicine Tel\u00a0Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-1922","authenticated-orcid":false,"given":"Liat","family":"Gindes","sequence":"additional","affiliation":[{"name":"Multidisciplinary Fetal Neurology Center, Wolfson Medical Center  Holon Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Leibovitz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"},{"name":"Obstetrics &amp; Gynecology Ultrasound Unit Bnai Zion Medical Center  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-0190","authenticated-orcid":false,"given":"Liat","family":"Ben\u2010Sira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"},{"name":"Pediatric Radiology, Department of Radiology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tally","family":"Lerman\u2010Sagie","sequence":"additional","affiliation":[{"name":"Multidisciplinary Fetal Neurology Center, Wolfson Medical Center  Holon Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel\u00a0Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64029-1.00001-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.06.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1006623"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/uog.3909","article-title":"guidelines for performing the \u2018basic examination\u2019 and the \u2018fetal neurosonogram\u2019","volume":"29","author":"Sonographic examination of the fetal central nervous system","year":"2007","journal-title":"Ultrasound Obstet Gynecol."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2021.08.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811431825"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15665"},{"issue":"12","key":"e_1_2_10_9_1","article-title":"Fetal Neurology: From Prenatal Counseling to Postnatal Follow\u2010Up","volume":"12","author":"Scelsa B.","year":"2022","journal-title":"Diagnostics (Basel)."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5508-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31723-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4836-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11311.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.05.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32042-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14604"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61705-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6339"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24885"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14735"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg-2023-109293"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6447"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15043"},{"issue":"3","key":"e_1_2_10_24_1","article-title":"Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta\u2010analysis","volume":"138","author":"D'Antonio F","year":"2016","journal-title":"Pediatrics."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6382"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0872-8"},{"key":"e_1_2_10_27_1","article-title":"Spectrum of brain malformations in fetuses with \u2018mild\u2019 tubulinopathies","author":"Hagege R","year":"2022","journal-title":"Ultrasound Obstet Gynecol."}],"container-title":["Developmental Medicine &amp; 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