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The short\u2010term study intervention was 200\u2009mg of lamotrigine taken orally for 26\u2009weeks. The primary outcome was performance IQ tested with the Wechsler Intelligence Scale for Children, Third Edition, complemented with secondary outcomes for visuospatial learning efficacy, visual perception, visual sustained attention, fine motor coordination, attention\u2010deficit\/hyperactivity problems, and executive functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 402 adolescents with NF1, of whom 31 (eight females) entered the study. Complete\u2010case analysis showed no effect of lamotrigine on either performance IQ (\u22120.23, 95% CI \u22126.90 to 6.44) or most secondary outcomes. Visual sustained attention showed a trend towards better performance in the lamotrigine group (\u22120.81, 95% CI \u22121.67 to 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Lamotrigine did not improve cognitive functioning in adolescents with NF1. The small treatment effects make it unlikely that a larger sample size could have changed this conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.16094","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T15:14:29Z","timestamp":1727536469000},"page":"537-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lamotrigine for cognitive deficits associated with neurofibromatosis type 1: A phase <scp>II<\/scp> randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-7752","authenticated-orcid":false,"given":"Myrthe J.","family":"Ottenhoff","sequence":"first","affiliation":[{"name":"Department of Neuroscience Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-8095","authenticated-orcid":false,"given":"Sabine E.","family":"Mous","sequence":"additional","affiliation":[{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Child and Adolescent Psychiatry and Psychology Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Child Brain Center, Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-9878","authenticated-orcid":false,"given":"Jesminne","family":"Castricum","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Psychiatry Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-0836","authenticated-orcid":false,"given":"Andr\u00e9 B.","family":"Rietman","sequence":"additional","affiliation":[{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Child and Adolescent Psychiatry and Psychology Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Child Brain Center, Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8934","authenticated-orcid":false,"given":"Rianne","family":"Oostenbrink","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus Medical Center Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-4027","authenticated-orcid":false,"given":"Thijs","family":"van der Vaart","sequence":"additional","affiliation":[{"name":"Erasmus MC Center of Expertise for Neurodevelopmental Disorders (ENCORE) Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Neurology Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8488-6536","authenticated-orcid":false,"given":"Joke H. 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