{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:28:22Z","timestamp":1788028102591,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify neonatal magnetic resonance imaging (MRI) features that predict the likelihood of children with congenital cytomegalovirus (cCMV) developing epilepsy, together with clinical features and a validated MRI scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a retrospective descriptive cohort study of infants with cCMV referred to a paediatric infectious disease centre between April 2012 and March 2022, and followed up for at least 2\u2009years. MRI was performed before 4\u2009months of age and assessed by two paediatric neuroradiologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety children with cCMV were included, 46 were female and 44 were male. The median age at MRI was 20\u2009days, (standard deviation\u2009=\u200934, range\u2009=\u20091\u2013200). Seventy\u2010two of 90 children were symptomatic at birth and 7 of 72 developed epilepsy (9.7% of symptomatic infants, 7.8% of total). None of 18 asymptomatic children developed epilepsy. Those with epilepsy were more likely to be symptomatic at birth (100% vs. 76%, <jats:italic>p<\/jats:italic>\u2009=\u20090.14) and to have cortical malformations (86% vs. 15%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Infants with polymicrogyria (PMG) were more likely to develop epilepsy (odds ratio\u2009=\u200935 [3.9\u2013317.1], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A 1\u2010year remission was achieved in three of seven children; four required multiple antiseizure medications without remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The strongest correlate of epilepsy development was PMG. Infants with symptomatic cCMV at birth and PMG were more likely to develop epilepsy, and were likely to require one or more antiseizure medications. Parents of infants with cCMV and cortical malformations should be counselled regarding this risk. Including PMG severity in cCMV MRI scoring could improve epilepsy risk prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.16250","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:33:50Z","timestamp":1737981230000},"page":"1026-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymicrogyria in infants with symptomatic congenital cytomegalovirus at birth is associated with epilepsy: A retrospective, descriptive cohort study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-0010","authenticated-orcid":false,"given":"George","family":"Lawson","sequence":"first","affiliation":[{"name":"Department of Paediatric Infectious Diseases Imperial College Healthcare NHS Trust  London UK"},{"name":"Department of Infection UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-0661","authenticated-orcid":false,"given":"Alexander","family":"Sheeka","sequence":"additional","affiliation":[{"name":"Department of Imaging Imperial College Healthcare NHS Trust  London UK"},{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-9655","authenticated-orcid":false,"given":"Pritika","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Imaging Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Alifieraki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Basheer","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8803-7080","authenticated-orcid":false,"given":"Wajanat","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Imaging Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-0944","authenticated-orcid":false,"given":"Carolina","family":"Kachramanoglou","sequence":"additional","affiliation":[{"name":"Department of Imaging Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-1833","authenticated-orcid":false,"given":"Hermione","family":"Lyall","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20736"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(17)30197-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1938"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100892"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.409"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5819"},{"key":"e_1_2_10_9_1","first-page":"1068","article-title":"Outcome of confirmed symptomatic congenital cytomegalovirus infection","volume":"66","author":"Ramsay MEB","year":"1991","journal-title":"ADC."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112061"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.12.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8111040"},{"key":"e_1_2_10_13_1","article-title":"Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities","author":"Alarc\u00f3n A","year":"2023","journal-title":"Arch Dis Child \u2010 Fetal Neonatal Ed."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-08"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102054"},{"issue":"1","key":"e_1_2_10_16_1","article-title":"A congenital CMV infection model for follow\u2010up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. 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