{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:04:56Z","timestamp":1791669896986,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the factors influencing height, weight, and body mass index (BMI) z\u2010scores, and the relationship between them and motor performance, in boys with Duchenne muscular dystrophy (DMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a randomized, double\u2010blind, parallel group trial involving 32 study sites across five countries. Height, weight, BMI z\u2010scores, and clinical outcome assessments (COAs)\u2014rise from supine velocity, 10\u2010m walk\/run velocity, NorthStar Ambulatory Assessment, and 6\u2010minute walk test\u2014were analysed in 4\u2010year\u2010old to 7\u2010year\u2010old boys with DMD randomized to 0.75\u2009mg\/kg\/day prednisone, 0.75\u2009mg\/kg\/day intermittent prednisone, or 0.90\u2009mg\/kg\/day deflazacort in the FOR\u2010DMD study. Trajectories were modelled using a linear mixed\u2010effects model and correlations were explored through Spearman's partial correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 194 boys with DMD, higher height at glucocorticoid initiation was associated with slower growth (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001) and older age was associated with increased weight gain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Glucocorticoid type and regimen influenced height and weight trajectories but not BMI. Changes in height and weight z\u2010scores were negatively correlated with COAs (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05 in all cases). Correlations were weak 3\u2009years after glucocorticoid initiation and moderate after 5\u2009years (closer to the age of loss of ambulation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Changes in anthropometric measures after glucocorticoid initiation are associated with COA performance and larger correlations closer to the age of loss of ambulation. This emphasizes the need for weight management strategies and discussions that support treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.16437","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T01:29:25Z","timestamp":1756690165000},"page":"429-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Height, weight, and body mass index trajectories and their correlation with functional outcome assessments in boys with Duchenne muscular dystrophy"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-265X","authenticated-orcid":false,"given":"Marianela","family":"Schiava","sequence":"first","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh J.","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Carleton University  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Wood","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"},{"name":"Great North Children's Hospital Royal Victoria Infirmary  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Choong","family":"Wong","sequence":"additional","affiliation":[{"name":"Bone, Endocrine, Nutrition Research Group in Glasgow, Human Nutrition University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Children's Hospital of Eastern Ontario  Ottawa Ontario Canada"},{"name":"Department of Paediatrics University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Muni","family":"Lofra","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mayhew","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gregory","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Centre  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Guglieri","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the 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