{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:07:48Z","timestamp":1778954868819,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy and tolerability of intravenous immunoglobulin (IVIG) in reducing febrile status epilepticus in children with Dravet syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a retrospective multicentre study across seven French university hospitals (2005\u20132022). Children with genetically confirmed Dravet syndrome who received sequential IVIG were included. Clinical data were collected over two 6\u2010month periods: before and after IVIG initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen individuals (six males, eight females) were included. At IVIG initiation, all were in the stormy phase, aged 10 to 92\u2009months, and receiving a median of four antiseizure medications. IVIG was administered every 1 to 6\u2009weeks (0.3\u20130.5\u2009g\/kg per infusion). Hospitalizations for status epilepticus significantly decreased, from a median of 4 (range 0\u201316) at baseline to 1 (range 0\u20136) after treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Twelve individuals improved, two remained stable. Adverse events occurred in 6 out of 14 individuals, including infusion\u2010related fever or seizures. Central venous access was required in six cases. IVIG was continued beyond 6\u2009months in 11 out of 14 individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These series suggest a potential benefit of IVIG in reducing status epilepticus in selected children with Dravet syndrome. However, tolerability and feasibility issues were identified. A prospective controlled trial is warranted to further define the role of IVIG in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70077","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:31:12Z","timestamp":1763008272000},"page":"857-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous immunoglobulin and febrile status epilepticus in children with Dravet syndrome: A retrospective multicentre study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8088-2684","authenticated-orcid":false,"given":"Romane","family":"Marc","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology Reference Centre for Rare Epilepsies, CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Chemaly","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Reference Centre for Rare Epilepsies, Enfants Malades University Hospital, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Kuchenbuch","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine CHRU\u2010Nancy, Service de P\u00e9diatrie, Reference Centre for Rare Epilepsies  Nancy France"},{"name":"Universit\u00e9 de Lorraine, IMoPA  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Espil\u2010Taris","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Reference Centre for Rare Epilepsies, CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Lametery","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Grenoble University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Maurey","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Competence Centre for Rare Epilepsies, CHU Bic\u00eatre, Le Kremlin Bic\u00eatre  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylviane","family":"Peudenier","sequence":"additional","affiliation":[{"name":"Paediatrics Department CHU Brest, Centre de R\u00e9f\u00e9rence D\u00e9ficience Intellectuelle &amp; Polyhandicap de Causes Rares  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-0120","authenticated-orcid":false,"given":"Sylvie","family":"Nguyen The Tich","sequence":"additional","affiliation":[{"name":"CHU Lille, Reference Centre for Rare Epilepsies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Nabbout","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Reference Centre for Rare Epilepsies, Enfants Malades University Hospital, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Institut Imagine INSERM UMR 1163, Translational Research on Neurological Diseases, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-0211","authenticated-orcid":false,"given":"Claire","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Reference Centre for Rare Epilepsies, CHU Bordeaux  Bordeaux France"},{"name":"CNRS, INCIA, UMR 5287, NRGen Team, University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17239"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17274"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws151"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13591"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2019.02.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00898-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16334"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.13036"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12192417"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201018666170915123700"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02221.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.03.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071468"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.10.020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954498"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02592447"},{"issue":"12","key":"e_1_2_8_20_1","article-title":"Intravenous immunoglobulins for epilepsy","author":"Geng J","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.12.018"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02640.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12371"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109802"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14038"},{"issue":"12","key":"e_1_2_8_27_1","article-title":"Intravenous immunoglobulins for epilepsy","author":"Geng J","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17391"}],"container-title":["Developmental Medicine &amp; 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