{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:07:47Z","timestamp":1778954867868,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To systematically review and characterize the spectrum of non\u2010epileptic paroxysmal events in individuals with Rett syndrome (RTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a\u00a0descriptive systematic review of observational evidence. Searches were conducted across the PubMed, Embase, and OVID databases for studies published from January 1962 to September 2024. Eligible studies included case reports, case series, cohort studies, and small clinical trials that described non\u2010epileptic events in individuals with clinically or genetically confirmed RTT. Data were extracted on study design, participant characteristics, and event types. Events were categorized into respiratory, neuromotor, and behavioural domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010two studies met the inclusion criteria, representing a wide age range of individuals with RTT. The most frequently reported paroxysmal non\u2010epileptic events were respiratory disturbances, including breath\u2010holding and hyperventilation, followed by vacant spells, involuntary movements, and behavioural episodes such as agitation and inappropriate laughter. Discrepancies were noted between the diagnostic attribution of clinician\u2010reported and family\u2010reported events. The term \u2018Rett episodes\u2019 was used by a minority of authors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>A wide range of non\u2010epileptic paroxysmal events requiring different treatment approaches are experienced by patients with RTT. Enhancing clinician awareness and developing clearer diagnostic frameworks are key to improving classification accuracy and preventing unnecessary treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70093","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:00:58Z","timestamp":1764046858000},"page":"746-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010epileptic paroxysmal events in Rett syndrome: A systematic review of case\u2010based and observational evidence"],"prefix":"10.1111","volume":"68","author":[{"given":"Natasha","family":"Bhatti","sequence":"first","affiliation":[{"name":"East Kent Hospitals University NHS Foundation Trust, Kent and Canterbury Hospital  Canterbury Kent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-6177","authenticated-orcid":false,"given":"Daniel 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