{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:08Z","timestamp":1787014088706,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>After treatment with new disease\u2010modifying therapies, cognitive and neurodevelopmental aspects have been observed in individuals with spinal muscular atrophy (SMA). Emerging evidence suggests that children with SMA type 1 may experience cognitive, language, and behavioural delays, with reported rates of neurodevelopmental difficulties ranging from 9% to 60%. However, the evidence is inconclusive because of diagnostic inconsistencies and challenges in defining and categorizing cognitive, behavioural, and broader neurodevelopmental disorders. Some of these challenges are related to the difficulties in assessing children with severe motor, communication, or fatigue\u2010related impairments. Despite neurodevelopmental and cognitive aspects being relatively frequent in SMA type 1, the lack of systematic assessment methodologies and the presence of motor\u2010related testing biases hinder efforts to distinguish true neurodevelopmental disorders from the secondary effects of motor limitations, thus highlighting the unmet need of dedicated tools.<\/jats:p>","DOI":"10.1111\/dmcn.70112","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T04:46:33Z","timestamp":1764650793000},"page":"909-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cognitive and neurodevelopmental disorders in spinal muscular atrophy type I at the time of disease\u2010modifying therapies"],"prefix":"10.1111","volume":"68","author":[{"given":"Giorgia","family":"Coratti","sequence":"first","affiliation":[{"name":"Centro Clinico NeMO Child Neurology and Psychiatry Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Child Neuropsychiatry, Department of Life Sciences and Public Health Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Buchignani","sequence":"additional","affiliation":[{"name":"Department of Developmental Neuroscience IRCCS Fondazione Stella Maris  Pisa Italy"},{"name":"Department of Translational Research and of New Surgical and Medical Technologies University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-5365","authenticated-orcid":false,"given":"Eugenio","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Centro Clinico NeMO Child Neurology and Psychiatry Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Child Neuropsychiatry, Department of Life Sciences and Public Health Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-71"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(91)90051-S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001403"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2247"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.05.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00380-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2024.07.024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-024-07503-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-230136"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2023.11.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2024.07.448"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2023.02.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1326528"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864231154335"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2024.07.346"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq340"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000200193"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65578-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104870"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000144"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-221567"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14798"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973465"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2020.22.1\/macrocq"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17405620701345712"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00274-7"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2024.05.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1407341"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2023.08.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03261-z"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2022.05.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33677"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2017-0325"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-326613"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.05.010"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24203"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00048-2"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2023.07.095"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.16461"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-12484-8"},{"key":"e_1_2_8_44_1","volume-title":"StatPearls","author":"Scott HK","year":"2023"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.09.024"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0000000000000004"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:27:49Z","timestamp":1780583269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/dmcn.70112"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.70112","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"2025-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}