{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:02:35Z","timestamp":1789358555119,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS117544"],"award-info":[{"award-number":["R01 NS117544"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the long\u2010term efficacy of vagus nerve stimulation (VNS) in Dravet syndrome and identify key factors influencing treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a two\u2010center, retrospective cohort study of 15 patients (six females, nine males; median age at seizure onset 4\u2009months [range 2\u201312\u2009months]) with Dravet syndrome who underwent VNS implantation. Seizure frequency was evaluated over 12\u2009months and up to 10\u2009years after implantation. Linear mixed\u2010effects regression was used to analyze the impact of antiseizure medications (ASMs) and VNS parameters on seizure outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 50% or greater reduction in seizure frequency was observed in 93.3% (14 of 15) of patients at 12\u2009months and 86.7% (13 of 15) of patients across the 10\u2010year follow\u2010up. This seizure reduction was independent of ASM use; the VNS duty cycle was a significant predictor of seizure reduction. Two individuals (13.3%) experienced minor adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>VNS provides durable seizure reduction in Dravet syndrome, independent of ASM adjustments. These findings highlight the importance of early VNS initiation and parameter optimization in managing genetically defined epilepsy syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70127","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:56:37Z","timestamp":1768200997000},"page":"1072-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term seizure reduction with vagus nerve stimulation in Dravet syndrome"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-3607","authenticated-orcid":false,"given":"Sunanjay","family":"Bajaj","sequence":"first","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ivaniuk","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bruenger","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"},{"name":"Department of Neurosurgery, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samden D.","family":"Lhatoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia Pestana","family":"Knight","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Von Allmen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX 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