{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:55:24Z","timestamp":1786118124288,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the relationship between gestational age and clinical and magnetic resonance imaging (MRI) characteristics in infants with unilateral cerebral palsy (CP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a retrospective study of infants with unilateral CP in the Canadian CP Registry. Gestational age was considered as continuous and categorical. Neonatal signs were encephalopathy or seizures. M patterns were focal, white matter injury (WMI), and other. Additional impairments included seizures and non\u2010motor\u2010related impairments. The relationships between gestational age, imaging, and impairments were evaluated using multivariable and multinomial regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 826 participants: 572 (69.3%) were born at term (&gt;36.9\u2009weeks), 121 (14.6%) were born moderate\u2010to\u2010late preterm (32\u201336.9\u2009weeks), and 133 (16.1%) were born very\u2010to\u2010extremely preterm (&lt;\u200932\u2009weeks). Neonatal clinical signs (encephalopathy, seizures) were less common in infants born from 32 to 36.9\u2009weeks (odds ratio [OR]\u00a0=\u00a00.24, 95% confidence interval [CI]\u00a0=\u00a00.10\u20130.57) than infants born at term. Common MRI patterns were focal injury in 417 (68.2%) and WMI in 68 (11.1%). Focal injury increased with gestational age (OR\u00a0=\u00a01.06, 95% CI\u00a0=\u00a01.02\u20131.1), while WMI decreased (OR\u00a0=\u00a00.88, 95% CI\u00a0=\u00a00.83\u20130.93). Impairments did not vary with gestational age but were associated with specific MRI patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Most children with unilateral CP are born at term without neonatal signs of neurological injury. Gestational age at delivery was associated with neonatal signs and MRI pattern but not development of specific severe impairments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70177","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:21:32Z","timestamp":1770812492000},"page":"1269-1280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of unilateral cerebral palsy according to gestational age at birth: A retrospective study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0553-0030","authenticated-orcid":false,"given":"Johanie Victoria","family":"Pich\u00e9","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisa","family":"Hussein","sequence":"additional","affiliation":[{"name":"McGill University Health Research Institute  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kirton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-1028","authenticated-orcid":false,"given":"Darcy","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute, University of Toronto  Toronto Ontario Canada"},{"name":"Department of Pediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-0108","authenticated-orcid":false,"given":"Maryam","family":"Oskoui","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Montreal Children's Hospital\u2013McGill University Health Centre  Montreal, Quebec Canada"},{"name":"Department of Pediatrics &amp; Neurology\/Neurosurgery McGill University  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shevell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Montreal Children's Hospital\u2013McGill University Health Centre  Montreal, Quebec Canada"},{"name":"Department of Pediatrics &amp; Neurology\/Neurosurgery McGill University  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-9426","authenticated-orcid":false,"given":"Mary","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15346"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12080"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02047.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70294-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12331"},{"key":"e_1_2_8_7_1","article-title":"Neurodevelopmental profiles of children with unilateral cerebral palsy associated with middle cerebral artery and periventricular venous infarctions. 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