{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:56:27Z","timestamp":1786118187725,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004229","name":"Fondazione Pierfranco e Luisa Mariani","doi-asserted-by":"publisher","award":["R\u201019\u2010112\u00b0"],"award-info":[{"award-number":["R\u201019\u2010112\u00b0"]}],"id":[{"id":"10.13039\/501100004229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the natural history of newborn children with mild hypoxic\u2010ischaemic encephalopathy in the first year of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a multicentre, prospective observational study involving five neonatal intensive care units in an Italian region using both structured clinical and neurophysiological assessments according to the Italian Society of Neonatology guidelines. To make the clinical evaluation homogeneous at each centre, a training neurological courses was provided to all operators involved in the study. Forty newborn children (23 males and 17 females) underwent neonatal and infant neurological examination (Hammersmith Neonatal Neurological Examination and Hammersmith Infant Neurological Examination), brain magnetic resonance at 7 to 10\u2009days, electroencephalogram between 6 months and 12\u2009months, and Griffiths Scales of Child Development, Third Edition to assess neurodevelopmental outcome at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All of these infants demonstrated typical neuromotor development and age\u2010appropriate developmental quotients at 12\u2009months, even in the few showing abnormalities at magnetic resonance imaging assessment or neurological assessment during the neonatal period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Current classifications of mild hypoxic\u2010ischaemic encephalopathy may misclassify risk, highlighting the need for refined diagnostic criteria and early staging tools that can be used within the first 6\u2009hours of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70199","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:29:32Z","timestamp":1770107372000},"page":"1261-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early neurodevelopmental outcome in newborns with mild hypoxic\u2010ischaemic encephalopathy"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-1208","authenticated-orcid":false,"given":"Domenico M.","family":"Romeo","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Arpaia","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Di Malta","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pede","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia Maria","family":"Cicala","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ricci","sequence":"additional","affiliation":[{"name":"National Centre of Services and Research for the Prevention of Blindness and Rehabilitation of Visually Impaired, IAPB Italia Onlus  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Serrao","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-5365","authenticated-orcid":false,"given":"Eugenio","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-6367","authenticated-orcid":false,"given":"Claudia","family":"Brogna","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Fondazione Policlinico A. Gemelli, IRCCS  Rome Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Mild Encephalopathy Regional Network*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101265"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.11.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80132-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01809.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003810100488"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.93"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10024.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2608-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059416648044"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10509.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0136"},{"issue":"1","key":"e_1_2_8_14_1","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c363"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2022.12.004"},{"key":"e_1_2_8_17_1","volume-title":"Raccomandazioni per l'assistenza al neonato con Encefalopatia Ipossico\u2010Ischemica candidato al Trattamento Ipotermico III Edizione","author":"Gruppo di Studio di Neurologia Neonatale e Follow\u2010up","year":"2023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.02.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.164"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.02.008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0174-x"},{"key":"e_1_2_8_22_1","volume-title":"The Neurological Assessment of the Preterm and Full\u2010term Newborn Infant","author":"Dubowitz L.","year":"1999"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12876"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111879"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214423"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.04.011"},{"key":"e_1_2_8_27_1","volume-title":"Griffiths scales of child development","author":"Green E","year":"2016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.4011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03537-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2025.03.003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.9119"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-03980-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02912-z"}],"container-title":["Developmental Medicine &amp; 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