{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:08:17Z","timestamp":1784106497368,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["349187"],"award-info":[{"award-number":["349187"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify neuroimaging and neurophysiological markers predictive of infantile\u2010onset and childhood\u2010onset epilepsy after neonatal stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective observational study included a population\u2010based cohort of 55 consecutive newborn infants (born between 34\u2009+\u20094 and 42\u2009+\u20092 gestational weeks; 23 females) with neonatal stroke, who were followed up (median\u00a0=\u00a080\u2009months, range\u00a0=\u00a033\u2013139\u2009months) for the epilepsy outcomes at ages 1\u2009year (infantile\u2010onset) and 4\u2009years (childhood\u2010onset). Outcome prediction was assessed in relation to neonatal magnetic resonance imaging, neonatal somatosensory evoked potentials, and electroencephalogram (EEG) findings from both the neonatal period and infancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When compared to 1\u2010year\u2010olds without epilepsy, children with infantile\u2010onset epilepsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) had infarction of the proximal middle cerebral artery, asymmetry in neonatal EEG, and unilaterally or bilaterally absent somatosensory evoked potentials significantly more often. They also had higher total and maximal hourly seizure burden during the neonatal period and recurrent epileptiform activity already in their first follow\u2010up EEG. In contrast, childhood\u2010onset epilepsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) was significantly linked only to asymmetry in neonatal EEG, compared with children without epilepsy at 4\u2009years of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Neonatal neuroimaging and neurophysiology, combined with follow\u2010up EEGs, enabled the identification of children at the highest risk for infantile\u2010onset epilepsy after neonatal stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70362","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:39:15Z","timestamp":1781239155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuroimaging and neurophysiology in infantile\u2010onset epilepsy after neonatal stroke"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-5108","authenticated-orcid":false,"given":"Sinikka","family":"La Grassa","sequence":"first","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Division of Child Neurology Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital (HUS)  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Mikkonen","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Division of Child Neurology Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital (HUS)  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Mets\u00e4ranta","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Pediatrics and Pediatric Research Center, Children's Hospital, University of Helsinki and HUS  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Toiviainen\u2010Salo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology HUS Diagnostic Center, Radiology, University of Helsinki and HUS  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-7061","authenticated-orcid":false,"given":"Sampsa","family":"Vanhatalo","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Department of Clinical Neurophysiology Children's Hospital, HUS Diagnostic Center, University of Helsinki and HUS  Helsinki Finland"},{"name":"BABA Center, Children's Hospital and Pediatric Research Center, University of Helsinki and HUS  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Lauronen","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Department of Clinical Neurophysiology Children's Hospital, HUS Diagnostic Center, University of Helsinki and HUS  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Nevalainen","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, full member of ERN EpiCARE  Helsinki Finland"},{"name":"Department of Clinical Neurophysiology Children's Hospital, HUS Diagnostic Center, University of Helsinki and HUS  Helsinki Finland"},{"name":"BABA Center, Children's Hospital and Pediatric Research Center, University of Helsinki and HUS  Helsinki 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