{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:29:57Z","timestamp":1786379397208,"version":"build-2736575974"},"reference-count":122,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2015727; ATM"],"award-info":[{"award-number":["2015727; ATM"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide a systematic overview of speech, language, and social abilities of people with Rett syndrome (RTT), and identify the most frequently used communication assessments in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic search of PubMed, CINAHL, ScienceDirect, ERIC, and speechBITE databases was conducted using terms synonymous with RTT, speech, language, social, and clinical assessment. Two independent reviewers screened abstracts; one reviewer conducted full\u2010text screening, communication\u2010related data extraction, and quality appraisal, with verification by a senior author of a subset of full\u2010text articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3091 papers were identified after removal of duplicates, of which 59 met inclusion criteria. Severe communication impairment emerged as a core feature of RTT, across classic and atypical variants, to differing degrees. Expressive language and speech production were most severely affected. Atypicality in all communication domains was reported both pre\u2010 and post\u2010regression. Genetic (e.g.\n                      <jats:italic>MECP2<\/jats:italic>\n                      variant) and developmental (e.g. age) factors modulated ability; poorer outcomes often linked to early truncations and large deletions. Most assessments relied on caregiver report.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Speech\u2013language difficulties are ubiquitous in RTT, ranging from mild to profound. Objective assessment is limited by severe motor\u2010speech impairment and a reliance on caregiver report; flexible and\/or more granular tools are necessary. The use of both objective (e.g. acoustic analysis) and subjective (e.g. caregiver recall) measures is warranted for characterizing speech\u2013language ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70429","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:49:34Z","timestamp":1786376974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Speech, language, social communication, and communication assessments in Rett syndrome: A systematic review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2326-8605","authenticated-orcid":false,"given":"Lucas N.","family":"Raniolo","sequence":"first","affiliation":[{"name":"Department of Audiology and Speech Pathology The University of Melbourne  Melbourne VIC Australia"},{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-1205","authenticated-orcid":false,"given":"Ruth O.","family":"Braden","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech Pathology The University of Melbourne  Melbourne VIC Australia"},{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-5543","authenticated-orcid":false,"given":"Jana","family":"von Hehn","sequence":"additional","affiliation":[{"name":"Rett Syndrome Research Trust  Trumbull CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-0641","authenticated-orcid":false,"given":"John","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"},{"name":"University of Melbourne Department of Paediatrics The Royal Children's Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-2696","authenticated-orcid":false,"given":"David N.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-8511","authenticated-orcid":false,"given":"David J.","family":"Amor","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"},{"name":"University of Melbourne Department of Paediatrics The Royal Children's Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-2631","authenticated-orcid":false,"given":"Adam P.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech Pathology The University of Melbourne  Melbourne VIC Australia"},{"name":"Redenlab Ltd.  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