{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:42:11Z","timestamp":1789468931396,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effects of pressure garment therapy (PGT) using a compressive Lycra sleeve on bimanual function in a large sample of children with unilateral cerebral palsy (CP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre, randomized, double\u2010blind placebo\u2010controlled clinical trial was conducted over 6\u2009months. Children with unilateral CP were recruited across seven French rehabilitation centres between 2013 and 2020. Children were randomly assigned to receive either the active PGT sleeve or a placebo PGT sleeve. The primary outcome was bimanual function, assessed by the Assisting Hand Assessment (AHA) score at 6\u2009months. Secondary outcomes included the Quality of Upper Extremity Skills Test score, quality of life, neuro\u2010orthopaedic examination results, and somatosensory evoked potentials (SEPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 101 children were randomized (mean age\u00a0[standard deviation] 7\u2009years 1\u2009month\u00a0[1\u2009year 6\u2009months]). At 6\u2009months, the AHA scores did not differ between groups (PGT 57.62\u00a0[0.97] vs placebo 57.63\u00a0[0.87]; mean difference\u2009\u2212\u20090.01 AHA units [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.99]). There were no significant differences in any of the SEP parameters measuring upper arm nerve function between the two groups. For example, the mean difference in interside latency\/amplitude for N9 SEPs was PGT 0.50\u00a0(0.09) versus placebo 0.50\u00a0(0.10); mean difference\u2009\u2212\u20090.01 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.96).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These findings suggest that this form of PGT using a compressive dynamic Lycra sleeve (4\u2009hours\/day over 6\u2009months at 15\u201325\u2009mmHg) does not provide clinically meaningful improvements in bimanual function or neurophysiological outcomes in children with unilateral CP. This suggests limited clinical use for this intervention in routine rehabilitation practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70513","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:10:02Z","timestamp":1789463402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pressure garment therapy and bimanual upper limb function in children with unilateral cerebral palsy: A randomized clinical trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-3910","authenticated-orcid":false,"given":"Laurent","family":"Beghin","sequence":"first","affiliation":[{"name":"CIC 1403 \u2013 Clinical Investigation Center, Lille University Hospital Inserm  Lille France"},{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, U1286 \u2013 INFINITE, Institute for Translational Research in Inflammation  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Gerard","sequence":"additional","affiliation":[{"name":"Pediatric Physical Medicine and Rehabilitation Center, CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-0580","authenticated-orcid":false,"given":"Guy","family":"Letellier","sequence":"additional","affiliation":[{"name":"Pediatric Physical Medicine and Rehabilitation Center (ESEAN\u2010APF)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Pediatric Physical Medicine and Rehabilitation Center APF  Creil France"},{"name":"Pediatric Physical Medicine and Rehabilitation Center  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Fritot","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Department, CHU Amiens  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8948-4387","authenticated-orcid":false,"given":"Guillaume","family":"Zavard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CHU Lille, Department of Physical Medicine and Rehabilitation, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Leroy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CHU Lille, Biostatistics Department, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Donskoff","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Department, Paul Dottin Center  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Toussaint\u2010Thorin","sequence":"additional","affiliation":[{"name":"Pediatric Physical Medicine and Rehabilitation Center, CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Medical\u2010Educational Institute for children and adolescents (IEM\/APF) Dabbadie Center  France"},{"name":"Physical Medicine and Rehabilitation Department, Marc Sautelet Center  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"12","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/dmcn.15346","article-title":"Global prevalence of cerebral palsy: A systematic analysis","volume":"64","author":"McIntyre S","year":"2022","journal-title":"Developmental Medicine and Child Neurology"},{"issue":"4","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/dmcn.70149","article-title":"Updated description of cerebral palsy","volume":"68","author":"Dan B","year":"2026","journal-title":"Developmental Medicine and Child Neurology"},{"issue":"7","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11070920","article-title":"Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21\u2009Years Old: A Systematic Review","volume":"11","author":"Martinie O","year":"2021","journal-title":"Brain Sciences"},{"issue":"8","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jhsa.2008.02.032","article-title":"Hand Function in Cerebral Palsy. 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