{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:39:56Z","timestamp":1792352396765,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["156216"],"award-info":[{"award-number":["156216"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the ability of the Hammersmith Infant Neurological Examination (HINE) at 3\u2009months 2\u2009weeks corrected age to identify developmental difficulties at 2\u2009years corrected age in infants born preterm between 29 and 36\u2009weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this prospective cohort study, the HINE was administered at 3\u2009months 2\u2009weeks corrected age. Development was assessed at 2\u2009years corrected age using the Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley\u20104) and MacArthur\u2013Bates Communicative Development Inventories. Developmental delay was defined using Bayley\u20104 scores less than 1 SD below the mean; expressive language delay was defined as a score less than the 10th centile for the number of spoken words expected for age. The cohort was largely free of brain lesions typically associated with cerebral palsy (5% intraventricular hemorrhage, with no other major brain lesions reported). Associations were examined using linear regression, screening performance using receiver operating characteristic curves, and incremental predictive value by comparing adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      across models, including perinatal and socioenvironmental factors with and without the HINE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 174 infants were included in the analyses. The HINE total score was not associated with motor, cognitive, or language outcomes. Discriminative performance was poor (area under the curve\u00a0=\u00a00.48\u20130.57); adding the HINE total score to models including perinatal and socioenvironmental factors did not improve predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>A single HINE at 3\u2009months 2\u2009weeks corrected age has limited utility for identifying mild\u2010to\u2010moderate developmental difficulties in this population and should not be used alone to determine developmental surveillance needs. Longitudinal surveillance incorporating complementary sources of developmental, clinical, and socioenvironmental information may be more effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70574","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:02:08Z","timestamp":1792350128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hammersmith Infant Neurological Examination: Prediction of neurodevelopmental delay in children born between 29 and 36\u2009weeks of gestation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7104-1906","authenticated-orcid":false,"given":"L\u00e9anne","family":"Brabant","sequence":"first","affiliation":[{"name":"Centre de Recherche Azrieli of CHU Sainte\u2010Justine  Montr\u00e9al Canada"},{"name":"School of Rehabilitation Universit\u00e9 de Montr\u00e9al  Montr\u00e9al 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