{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:58Z","timestamp":1792043218986,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006126","name":"Hospital for Sick Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify structural signatures of cerebral palsy (CP) motor impairment and selective dorsal rhizotomy (SDR) outcomes using spinal cord deformation\u2010based morphometry (scDBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This retrospective study quantifies spinal cord structural abnormalities in 39 children with CP, stratified by the baseline motor function (Gross Motor Function Classification System [GMFCS] levels I\u2013II,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200921 and GMFCS level\u2009&gt;\u2009II,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200918). T1\u2010weighted clinical images were non\u2010linearly registered to a healthy normative template. Localized spinal cord tissue volume change was modeled against baseline Gross Motor Function Measure (GMFM\u201066) and 12\u2010month postSDR improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In children with ambulatory impairment (GMFCS level\u2009&gt;\u2009II,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200918), lower motor capacity correlated with localized rostral cervical (C1\u2013C4) deformation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05); no correlates were identified in GMFCS levels I to II (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200921). Clinical improvement after SDR was associated with baseline C1 dimensions closer to normative adult values, specifically involving reticulospinal and vestibulospinal tracts (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Spinal cord morphology reflects motor potential and surgical outcomes in CP (GMFCS level\u2009&gt;\u2009II). Localizing C1 structural deficit, scDBM may provide an objective structural signature of severity to identify presurgical candidates with the necessary reserve to translate spasticity reduction into clinically meaningful motor gains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.70576","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:05:25Z","timestamp":1792040725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical cord deformation in cerebral palsy: Structural signatures of gross motor function and outcomes after selective dorsal rhizotomy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-6890","authenticated-orcid":false,"given":"Timur H.","family":"Latypov","sequence":"first","affiliation":[{"name":"Neurosciences and Mental Health SickKids Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Mithani","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health SickKids Research Institute  Toronto Ontario Canada"},{"name":"Division of Neurosurgery The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4162-2537","authenticated-orcid":false,"given":"Sara","family":"Breitbart","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Douglas","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Gill","sequence":"additional","affiliation":[{"name":"Ambulatory Services\u2014Selective Dorsal Rhizotomy Program Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Cotton","sequence":"additional","affiliation":[{"name":"Ambulatory Services\u2014Selective Dorsal Rhizotomy Program Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Ambulatory Services\u2014Selective Dorsal Rhizotomy Program Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Chin\u2010A\u2010Young","sequence":"additional","affiliation":[{"name":"Ambulatory Services\u2014Selective Dorsal Rhizotomy Program Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golda","family":"Milo\u2010Manson","sequence":"additional","affiliation":[{"name":"Division of Developmental Paediatrics, Department of Paediatrics Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-1028","authenticated-orcid":false,"given":"Darcy","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Division of Developmental Paediatrics, Department of Paediatrics Holland Bloorview Kids Rehabilitation Hospital  Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-8184","authenticated-orcid":false,"given":"George M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health SickKids Research Institute  Toronto Ontario Canada"},{"name":"Division of Neurosurgery The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.70149"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010022\u201005110\u20105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.05.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.03.031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2010.07.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.70262"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14860"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005361"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125547"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.82"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010015\u20102614\u20109"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14320"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0771"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0862"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.10.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.041"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.12.PEDS19629"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2015.07.013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.08.117"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.081"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25622"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.025"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.037"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14910"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0475"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12355"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.52294\/001c.133510"},{"key":"e_1_2_7_29_1","first-page":"8","article-title":"A report: the definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum P","year":"2007","journal-title":"Dev Med Child Neurol Suppl."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.11.1357"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.2005.tb03071.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e89"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108749.2008.03089.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2024.101673"},{"issue":"3","key":"e_1_2_7_35_1","doi-asserted-by":"crossref","DOI":"10.1097\/BPO.0000000000002878","article-title":"The Effect of Selective Dorsal Rhizotomy on Scoliosis in Children With Cerebral Palsy: A Long\u2010term Follow\u2010up Study","volume":"45","author":"Miller SD","year":"2025","journal-title":"J Pediatr Orthop"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2022\u2010005657"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.215160"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3368\u201016.2017"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1282685","article-title":"Moving toward elucidating alternative motor pathway structures post\u2010stroke: the value of spinal cord neuroimaging","volume":"15","author":"Oquita R","year":"2024","journal-title":"Front Neurol"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0735\u201009.2009"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci6040049"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15765"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2018.12.010"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108749.2008.03150.x"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.70576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.70576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.70576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:05:27Z","timestamp":1792040727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.70576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":43,"alternative-id":["10.1111\/dmcn.70576"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.70576","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dmcn.70576"}}