{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:16:11Z","timestamp":1767705371962},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T00:00:00Z","timestamp":1363478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We prospectively evaluated the effect of insulin intensification on glycaemic control and lipid levels in children and young persons with Type\u00a01 diabetes in relation to ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the first 2\u00a0years of a 3\u2010year observation period, as part of routine clinical care, 231 children and young persons (40% white, 28% South Asian, 32% black) from a single clinic were offered intensive insulin therapy. After 2\u00a0years, 222 were on intensive therapy and their data were compared between ethnic groups at the end of year\u00a03.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed ethnic differences in HbA<jats:sub>1c<\/jats:sub> levels during the study [study beginning and end: white children and young persons 77 and 70\u00a0mmol\/mol (9.2 and 8.6%) vs. South Asian 72 and 68\u00a0mmol\/mol (8.7 and 8.4%) vs. black 83 and 79\u00a0mmol\/mol (9.7 and 9.4%), <jats:italic>P<\/jats:italic>\u2010value for <jats:styled-content style=\"fixed-case\">ANCOVA<\/jats:styled-content>\u00a0=\u00a00.007]. By study end, South Asians had the lowest <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol (2.0 vs. 1.4 vs. 1.6\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.03) and highest triglyceride levels (0.9 vs. 1.8 vs. 1.0\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.001). In linear mixed modelling, after adjustment for socio\u2010economic deprivation and other covariates: (1) black ethnicity was associated with poorer glycaemic control (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and (2) South Asian ethnicity was associated with higher triglyceride levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), independent of HbA<jats:sub>1c<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effect of insulin intensification on glycaemic control and lipid profile in children and young persons with Type\u00a01 diabetes differs in relation to ethnic group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12022","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T14:25:06Z","timestamp":1348237506000},"page":"495-501","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of insulin intensification in children and young persons with Type\u00a01 diabetes differs in relation to ethnic group; a prospective observational study"],"prefix":"10.1111","volume":"30","author":[{"given":"R. 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