{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:39:58Z","timestamp":1779910798109,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aimed to investigate arterial stiffness in subjects with normal glucose tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, systolic blood pressure, fasting plasma glucose, lipid variables, ankle\u2013brachial pressure index and brachial\u2013ankle pulse wave velocity were measured in 2059 subjects from Takasaki city, located approximately 100\u00a0km north of Tokyo in Japan. Following a 75\u2010g oral glucose tolerance test, only subjects with normal glucose tolerance were selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hour post\u2010challenge plasma glucose levels were correlated with brachial\u2013ankle pulse wave velocity values (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.340, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). When subjects with normal glucose tolerance were divided into three groups\u2014group\u00a01 (1\u2010h plasma glucose &lt;\u00a08.56\u00a0mmol\/l, <jats:italic>n<\/jats:italic>\u00a0=\u00a01595), group\u00a02 (1\u2010h plasma glucose \u2265\u00a08.56 and &lt;\u00a010.17\u00a0mmol\/l, <jats:italic>n<\/jats:italic>\u00a0=\u00a0334) and group\u00a03 (1\u2010h plasma glucose \u2265\u00a010.17\u00a0mmol\/l, <jats:italic>n<\/jats:italic>\u00a0=\u00a0130)\u2014the brachial\u2013ankle pulse wave velocity of group\u00a03 (1473\u00a0\u00b1\u00a0322\u00a0cm\/s) was significantly higher than that of group\u00a02 (1355\u00a0\u00b1\u00a0252\u00a0cm\/s) and brachial\u2013ankle pulse wave velocity of group\u00a02 was also significantly higher than that of group\u00a01 (1275\u00a0\u00b1\u00a0212\u00a0cm\/s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have identified that, in normal glucose tolerance, arterial stiffness is advanced in subjects with higher 1\u2010h post\u2010challenge plasma glucose in spite of the normal range for <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, systolic blood pressure, fasting plasma glucose and lipid variables. Higher 1\u2010h plasma glucose level is a risk factor for arterial stiffness in normal glucose tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12026","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T18:10:08Z","timestamp":1348596608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Elevated 1\u2010h plasma glucose following 75\u2010g oral glucose load is a predictor of arterial stiffness in subjects with normal glucose tolerance"],"prefix":"10.1111","volume":"29","author":[{"given":"K.","family":"Niijima","sequence":"first","affiliation":[{"name":"Kan\u2010etsu Chuo Hospital Takasaki Gunma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Muranaka","sequence":"additional","affiliation":[{"name":"Kan\u2010etsu Chuo Hospital Takasaki 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