{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:56:59Z","timestamp":1769201819814,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The calcineurin inhibitors cyclosporine and tacrolimus are implicated in post\u2010transplant complications such as new\u2010onset diabetes after transplantation. The relative contribution of each calcineurin inhibitor to new\u2010onset diabetes after transplantation remains unclear. We sought to compare the impact of cyclosporine and tacrolimus on glucose metabolism in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight haemodialysis patients received 8\u201310\u00a0days of oral treatment followed by 5\u2010h infusions with cyclosporine, tacrolimus and saline in a randomized, investigator\u2010blind, crossover study. Glucose metabolism and \u03b2\u2010cell function was investigated through: a hyperinsulinaemic\u2013euglycaemic clamp, an intravenous glucose tolerance test and insulin concentration time series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cyclosporine and tacrolimus decreased insulin sensitivity by 22% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and 13% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048), respectively. The acute insulin response and pulsatile insulin secretion were not significantly affected by the drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, 8\u201310\u00a0days of treatment with cyclosporine and tacrolimus impairs insulin sensitivity to a similar degree in haemodialysis patients, while acute insulin responses and pulsatile insulin secretion remain unaffected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12028","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T18:18:45Z","timestamp":1348597125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The impact of calcineurin inhibitors on insulin sensitivity and insulin secretion: a randomized crossover trial in uraemic patients"],"prefix":"10.1111","volume":"29","author":[{"given":"L. 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