{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:36:28Z","timestamp":1780050988660,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Compared with women with uncomplicated pregnancies, women with a history of pre\u2010eclampsia have two to five times the risk of cardiovascular disease. It is not known whether this risk is related to albuminuria, a known cardiovascular risk factor that is part of the definition of pre\u2010eclampsia and that often persists after delivery. Our objective was to determine if the high risk of cardiovascular disease in women with pre\u2010eclampsia is accounted for by known cardiovascular risk factors including albuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional analysis of 4080 dysglycaemic women enrolled in a large randomized controlled trial who provided an obstetric history and had at least one delivery. Blood pressure, height, weight, waist circumference and hip circumference were measured. An oral glucose tolerance test, lipids, an electrocardiogram and an albumin\/creatinine ratio from a first morning urine sample were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 3613 women with no history of pre\u2010eclampsia during their pregnancies, 108 with severe pre\u2010eclampsia and 359 with non\u2010severe pre\u2010eclampsia. Women with a history of severe pre\u2010eclampsia had higher rates of previous cardiovascular disease than women with non\u2010severe pre\u2010eclampsia or women without pre\u2010eclampsia (87, 72 and 72%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0019). The high risk of previous cardiovascular disease in women with a history of severe pre\u2010eclampsia (odds ratio 2.67, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.52\u20134.70) persisted after adjustment for albuminuria (odds ratio\u00a02.74, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.55\u20134.83) and also after adjusting for other covariates including albuminuria (odds ratio\u00a03.03, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.69\u20135.44).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even after accounting for cardiovascular risk factors including albuminuria, a history of severe pre\u2010eclampsia is independently associated with a threefold higher risk of cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12033","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:04:26Z","timestamp":1349913866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increased cardiovascular risk after pre\u2010eclampsia in women with dysglycaemia"],"prefix":"10.1111","volume":"30","author":[{"given":"S. D.","family":"McDonald","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Hamilton ON Canada"},{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Division of Cardiology Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Division of Nephrology Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lonn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Division of Cardiology Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pogue","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Islam","sequence":"additional","affiliation":[{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Devereaux","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Division of Cardiology Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Hamilton ON Canada"},{"name":"Department of Medicine Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton ON Canada"},{"name":"Division of Endocrinology and Metabolism McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90653-O"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67726-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6966.1395"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90782-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.042"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285287"},{"key":"e_1_2_8_9_1","first-page":"26","article-title":"Origin Trial Investigators. 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