{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:10:52Z","timestamp":1761059452853},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Lower\u2010extremity amputation in patients with diabetes is associated with premature mortality and impaired ambulatory status. Despite advances in limb salvage techniques, certain patients will require major amputation. The hypothesis of this study is that self\u2010reported outcomes of patients with non\u2010reconstructable Charcot neuroarthropathy and chronic osteomyelitis improve after trans\u2010tibial amputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010reported outcome was assessed using the Medical Outcome Study Short Form 36\u2010item health survey (SF\u201036) and the Foot and Ankle Ability Measure. The study group included 13 patients with diabetes who underwent a trans\u2010tibial amputation and completed both the Medical Outcome Study SF\u201036 and the Foot and Ankle Measure pre\u2010 and post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvement after trans\u2010tibial amputation occurred in the SF\u201036 Physical Component Summary score and both the Foot and Ankle Measure Activity of Daily Living and Sports scores at a mean follow\u2010up of 79\u00a0weeks (range 53\u2013122\u00a0weeks). Although the SF\u201036 Mental Component Summary score improved, the improvement did not achieve statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.30). Twelve of the 13 patients were satisfied with the amputation and had no reservations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a select group of Charcot neuroarthropathy patients with chronic osteomyelitis, trans\u2010tibial amputation resulted in improvement in self\u2010reported outcomes. Although major lower\u2010extremity amputation is a devastating complication in patients with diabetes, the results of this study provides some evidence for optimism in these high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12060","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T04:28:23Z","timestamp":1352176103000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Self\u2010reported outcomes of trans\u2010tibial amputations for non\u2010reconstructable Charcot neuroarthropathy in patients with diabetes: a preliminary report"],"prefix":"10.1111","volume":"30","author":[{"given":"D. K.","family":"Wukich","sequence":"first","affiliation":[{"name":"University of Pittsburgh Medical Center Comprehensive Foot and Ankle Center Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. T.","family":"Pearson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Comprehensive Foot and Ankle Center Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2011.02.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1360"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070502600910"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2009.0297"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2011.04.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.12.3333"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1799"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2008.1074"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070502600203"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1497"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200506000-00026"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2425"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1775"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0846"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2012.0113"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2012.0020"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:08:23Z","timestamp":1697454503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,20]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/dme.12060"],"URL":"https:\/\/doi.org\/10.1111\/dme.12060","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,20]]},"assertion":[{"value":"2012-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}