{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:15:55Z","timestamp":1792268155038,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Aims<\/jats:title>The aim was to evaluate the impact of family history of diabetes on the phenotype of patients diagnosed with Type\u00a02 diabetes and the frequency of susceptibility genotypes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with Type\u00a02 diabetes with family history for both Type\u00a01 and Type\u00a02 diabetes (FHMIX<\/jats:sub><\/jats:styled-content>, n<\/jats:italic>\u00a0=\u00a0196) or Type\u00a02 diabetes only (FHT<\/jats:sub><\/jats:styled-content>2<\/jats:sub>, n<\/jats:italic>\u00a0=\u00a0139) matched for age, sex, BMI<\/jats:styled-content> and age at diagnosis, underwent an oral glucose tolerance test and a combined glucagon test and insulin tolerance test. Glutamic acid decarboxylase (GAD<\/jats:styled-content>) antibodies and major Type\u00a01 and Type\u00a02 diabetes susceptibility gene variants were analysed. Patients were stratified into groups according to family history or GAD<\/jats:styled-content> antibody positivity (GADA<\/jats:styled-content>+, GADA<\/jats:styled-content>\u2013) or a combination of these (GADA<\/jats:styled-content>+\/FHMIX<\/jats:sub><\/jats:styled-content>,<\/jats:sub> GADA<\/jats:styled-content>+\/FHT<\/jats:sub><\/jats:styled-content>2,<\/jats:sub> GADA<\/jats:styled-content>\u2013\/FHMIX<\/jats:sub><\/jats:styled-content>,<\/jats:sub> GADA<\/jats:styled-content>\u2013\/FHT<\/jats:sub><\/jats:styled-content>2<\/jats:sub>).<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with other patients, those with FHMIX<\/jats:sub><\/jats:styled-content> more often had GAD<\/jats:styled-content> antibodies (14.3 vs. 4.3%, P<\/jats:italic>\u00a0=\u00a00.003), and those with both FHMIX<\/jats:sub><\/jats:styled-content> and GAD<\/jats:styled-content> antibodies had the highest frequency of insulin deficiency (stimulated serum C\u2010peptide <\u00a00.7\u00a0nmol\/l, GADA<\/jats:styled-content>+\/FHMIX<\/jats:sub><\/jats:styled-content> 46.4% vs. GADA<\/jats:styled-content>\u2013\/FHMIX<\/jats:sub><\/jats:styled-content> 9.5% (P<\/jats:italic>\u00a0<\u00a00.00001), GADA<\/jats:styled-content>\u2013\/FHT<\/jats:sub><\/jats:styled-content>2<\/jats:sub> 4.5% (P<\/jats:italic>\u00a0<\u00a00.00001), GADA<\/jats:styled-content>+\/FHT<\/jats:sub><\/jats:styled-content>2<\/jats:sub> 0%). Patients with GADA<\/jats:styled-content>+\/FHMIX<\/jats:sub><\/jats:styled-content> more often had HLA<\/jats:styled-content>\u2010DQB<\/jats:styled-content>1<\/jats:italic> risk genotypes compared with patients with GADA<\/jats:styled-content>\u2013\/FHMIX<\/jats:sub><\/jats:styled-content> or GADA<\/jats:styled-content>\u2013\/FHT<\/jats:sub><\/jats:styled-content>2D<\/jats:sub> (47 vs. 23 or 14%, P<\/jats:italic>\u00a0=\u00a00.05 and P<\/jats:italic>\u00a0<\u00a00.00001, respectively). In logistic regression analyses, FHMIX<\/jats:sub><\/jats:styled-content>, GAD<\/jats:styled-content> antibody positivity and HLA<\/jats:styled-content><\/jats:italic> risk genotypes were independently associated with insulin deficiency.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A family history for both type 1 and type 2 diabetes was associated with higher prevalence of GAD<\/jats:styled-content> antibodies and HLA<\/jats:styled-content>\u2010DQB<\/jats:styled-content>1<\/jats:italic> risk genotypes than a family history of type 2 diabetes only, and was associated with earlier and more severe development of insulin deficiency, which was only partially explained by GAD<\/jats:styled-content> antibodies and HLA<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12069","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T12:46:45Z","timestamp":1353070005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Family history of Type\u00a01 diabetes affects insulin secretion in patients with \u2018Type\u00a02\u2019 diabetes"],"prefix":"10.1111","volume":"30","author":[{"given":"V. M.","family":"Lundgren","sequence":"first","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Research Program of Molecular Medicine University of Helsinki"},{"name":"Folkhalsan Research Centre Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Research Program of Molecular Medicine University of Helsinki"},{"name":"Folkhalsan Research Centre Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Isomaa","sequence":"additional","affiliation":[{"name":"Folkhalsan Research Centre Helsinki"},{"name":"Department of Social Services and Health Care Jakobstad Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tuomi","sequence":"additional","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Research Program of Molecular Medicine University of Helsinki"},{"name":"Folkhalsan Research Centre Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.2.359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.12.1557"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03062-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1468"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1696"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265396"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.5.589"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.574"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0747"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.150"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0513-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2188"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1457"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0089"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0299"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2378-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0923"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.11.1585"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01921.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1992.tb01813.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.482117"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930902911720"},{"key":"e_1_2_7_24_1","first-page":"870","article-title":"Triple\u2010label hybridization assay for Type\u00a01 diabetes\u2010related HLA alleles","volume":"18","author":"Sjoroos M","year":"1995","journal-title":"Biotechniques"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1120"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03186.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.12.3193"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051558"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.12.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0579"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.157016"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:25:09Z","timestamp":1695572709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/dme.12069"],"URL":"https:\/\/doi.org\/10.1111\/dme.12069","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]},"assertion":[{"value":"2012-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}