{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:05:02Z","timestamp":1767164702206,"version":"build-2238731810"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n To analyse the effects of hyperglycaemia and blood pressure, diabetes and anti\u2010hypertension treatment on total and various types of cardiovascular disease incidence in patients with Type 2 diabetes followed for 30\u00a0years.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 740 incident patients with Type 2 diabetes were registered at the Lax\u00e5 Primary Health Care Centre, Sweden between 1972 and 2001. Information on systolic, diastolic, and mean arterial blood pressure, mean fasting blood glucose, type of diabetes and anti\u2010hypertension treatment was obtained from the patient records, and information on cardiovascular disease, myocardial infarction and stroke events from National Registers.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During the follow\u2010up period the cumulative incidence of cardiovascular disease increased significantly with male sex (\n HR<\/jats:styled-content>\n 1.52, 95%\n CI<\/jats:styled-content>\n 1.25\u20131.85), age (\n HR<\/jats:styled-content>\n 1.05, 95%\n CI<\/jats:styled-content>\n 1.04\u20131.07), year of diabetes onset (\n HR<\/jats:styled-content>\n 1.03, 95%\n CI<\/jats:styled-content>\n 1.01\u20131.05),\n BMI<\/jats:styled-content>\n , (\n HR<\/jats:styled-content>\n 1.04, 95%\n CI<\/jats:styled-content>\n 1.02\u20131.07), mean arterial blood pressure (\n HR<\/jats:styled-content>\n 1.04, 95%\n CI<\/jats:styled-content>\n 1.02\u20131.05) and number of previous cardiovascular disease events (\n HR<\/jats:styled-content>\n 1.15, 95%\n CI<\/jats:styled-content>\n 1.10\u20131.21), and decreased significantly with sulfonylurea treatment (\n HR<\/jats:styled-content>\n 0.64, 95%\n CI<\/jats:styled-content>\n 0.49\u20130.84), insulin (\n HR<\/jats:styled-content>\n 0.57, 95%\n CI<\/jats:styled-content>\n 0.33\u20130.98) and calcium channel blocker treatment (\n HR<\/jats:styled-content>\n , 0.69, 95%\n CI<\/jats:styled-content>\n 0.48\u20130.99). Cumulative incidence of myocardial infarction increased significantly with male sex, age,\n BMI<\/jats:styled-content>\n , mean arterial blood pressure, number of previous myocardial infarction events and diuretic treatment, and decreased with metformin treatment. Cumulative incidence of stroke increased with age, year of diabetes onset, mean arterial blood pressure, and previous number of stroke events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Cumulative cardiovascular disease, myocardial infarction and incidence of stroke increased with number of previous events and presence of hypertension and decreased with pharmacological anti\u2010diabetic treatment and, to a lesser extent, with anti\u2010hypertension treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dme.12106","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T05:27:14Z","timestamp":1356326834000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retracted: Effects of fasting blood glucose, diabetes treatment, blood pressure and anti\u2010hypertension treatment on cardiovascular disease incidence: a 30\u2010year follow\u2010up study of 740 incident patients with Type 2 diabetes"],"prefix":"10.1111","volume":"30","author":[{"given":"S. P. O.","family":"Jansson","sequence":"first","affiliation":[{"name":"Family Medicine Research Centre \u00d6rebro County Council School of Health and Medical Sciences \u00d6rebro University Sweden"},{"name":"Uppsala University Department of Public Health and Caring Sciences Family Medicine and Preventive Medicine Section Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K. G.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Uppsala University Department of Public Health and Caring Sciences Family Medicine and Preventive Medicine Section Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sv\u00e4rdsudd","sequence":"additional","affiliation":[{"name":"Uppsala University Department of Public Health and Caring Sciences Family Medicine and Preventive Medicine Section Uppsala 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