{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:43:07Z","timestamp":1696225387688},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate which triple oral therapy between metformin\u00a0+\u00a0pioglitazone\u00a0+\u00a0sitagliptin and metformin\u00a0+\u00a0pioglitazone\u00a0+\u00a0glibenclamide can be more useful in improving glycaemic control and should be preferred in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the 2\u2010year run\u2010in period, patients were instructed to take metformin monotherapy for the first year, then a combination of metformin and pioglitazone for the second year, then patients were randomized to add glibenclamide or sitagliptin to the dual combination of metformin and pioglitazone for another year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight reached with sitagliptin at 36\u00a0months was lower than that reached with glibenclamide. Fasting plasma insulin and homeostasis model assessment of insulin resistance were significantly increased by triple therapy with glibenclamide and decreased by that with sitagliptin. While sitagliptin did not change homeostasis model assessment of \u03b2\u2010cell function, this value was significantly increased by glibenclamide. Fasting plasma proinsulin was not influenced by triple oral therapy including glibenclamide, while it was decreased by the therapy including sitagliptin compared to glibenclamide. Triple oral therapy with sitagliptin better improved \u03b2\u2010cell function measures compared with the glibenclamide therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sitagliptin should be preferred to glibenclamide as an addition to the metformin\u00a0+\u00a0pioglitazone combination for its better protection of \u03b2\u2010cell secretion and its neutral effect on body weight.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12158","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T23:34:00Z","timestamp":1361230440000},"page":"846-854","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A comparison between sitagliptin or glibenclamide in addition to metformin + pioglitazone on glycaemic control and \u03b2\u2010cell function: the triple oral therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"G.","family":"Derosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics University of Pavia Pavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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