{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:05:39Z","timestamp":1762430739655},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Rising rates of obesity have led to an increasing prevalence of Type\u00a02 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type\u00a02 diabetes, as existing data sets have focused on mature (&gt;\u00a040\u00a0years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overweight (with an additional risk factor) or obese adults (18\u201340\u00a0years) were recruited for the Sedentary Time And Diabetes (<jats:styled-content style=\"fixed-case\">STAND<\/jats:styled-content>) randomized controlled trial. Measures included an oral glucose tolerance test, HbA<jats:sub>1c<\/jats:sub>, biochemical and anthropometric data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ninety\u2010three individuals (68% female; median age 33.8\u00a0years; median <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 33.9\u00a0kg\/m<jats:sup>2<\/jats:sup>) were recruited. Forty\u2010three per cent had a first\u2010degree family history of Type\u00a02 diabetes. Previously undiagnosed Type\u00a02 diabetes was present in 4.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). Of participants, 18.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) had impaired glucose metabolism: 4.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) HbA<jats:sub>1c<\/jats:sub> \u2265\u00a048\u00a0mmol\/mol (6.5%); 9.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) HbA<jats:sub>1c<\/jats:sub> 42\u201346\u00a0mmol\/mol (6.0\u20136.4%); 3.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) Type\u00a02 diabetes on oral glucose tolerance test; 6.2% (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) isolated impaired glucose tolerance; 2.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) isolated impaired fasting glucose; 1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0113) had dyslipidaemia, 28.0% (<jats:italic>n<\/jats:italic>\u00a0=\u00a054) had hypertension, 31.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) were vitamin\u00a0D deficient and 7.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) had abnormal liver function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified a high prevalence of Type\u00a02 diabetes and impaired glucose regulation in overweight and obese younger adults. These findings require confirmation in a larger, representative, population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12173","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T18:57:30Z","timestamp":1363633050000},"page":"671-675","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence of diabetes and impaired glucose metabolism in younger \u2018at risk\u2019 <scp>UK<\/scp> adults: insights from the <scp>STAND<\/scp> programme of research"],"prefix":"10.1111","volume":"30","author":[{"given":"E. G.","family":"Wilmot","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester Leicester UK"},{"name":"Diabetes Research Unit University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Edwardson","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit University of Leicester Leicester UK"},{"name":"School of Sport Exercise and Health Sciences Loughborough University Loughborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J. H.","family":"Biddle","sequence":"additional","affiliation":[{"name":"School of Sport Exercise and Health Sciences Loughborough University Loughborough UK"},{"name":"NIHR Leicester\u2010Loughborough Diet Lifestyle and Physical Activity Biomedical Research Unit UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gorely","sequence":"additional","affiliation":[{"name":"School of Sport Stirling University Stirling UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Henson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester Leicester UK"},{"name":"Diabetes Research Unit University of Leicester Leicester UK"},{"name":"NIHR Leicester\u2010Loughborough Diet Lifestyle and Physical Activity Biomedical Research Unit UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Khunti","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit University of Leicester Leicester UK"},{"name":"NIHR Leicester\u2010Loughborough Diet Lifestyle and Physical Activity Biomedical Research Unit UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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