{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T15:33:56Z","timestamp":1782056036465,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the effect of ketoacidosis on measured 25\u2010hydroxyvitamin D3 in children with new onset Type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Measurement of <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and bicarbonate levels was carried out in children with newly diagnosed Type 1 diabetes at presentation with ketoacidosis. 25\u2010hydroxyvitamin D3 estimation was carried out at presentation (timepoint 1) and 1\u00a0month later (timepoint 2). There was no significant difference in the mean (\u00b1<jats:sc>sd<\/jats:sc>) 25\u2010hydroxyvitamin D3 levels [35.39 (\u00b125.79) vs 39.63 (\u00b148.03) nmol\/L; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.661) at the two timepoints in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Correlation analysis revealed a positive correlation between bicarbonate levels and timepoint 1, i.e. the lower the bicarbonate levels, the lower were the timepoint 1 levels and vice versa (correlation coefficient 0.538, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001). Timepoint 2 levels also showed a positive correlation with serum bicarbonate levels with a correlation coefficient of 0.379 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032). None of the variables other than bicarbonate,.(age, gender, BMI, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> or time), was found to have the predictive ability for timepoint1 levels. Similarly for predicting timepoint 2 levels, BMI was found to have independent predictive ability in addition to bicarbonate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe ketoacidosis, as judged by bicarbonate but not <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, may transiently lower 25\u2010hydroxyvitamin D3 levels in children with new onset Type 1 diabetes. Persistence of low 25\u2010hydroxyvitamin D3 levels after resolution of ketoacidosis suggests a state of permanent vitamin D deficiency in our patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12200","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T13:08:28Z","timestamp":1363957708000},"page":"829-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D levels during and after resolution of ketoacidosis in children with new onset Type 1 diabetes"],"prefix":"10.1111","volume":"30","author":[{"family":"Devidayal","sequence":"first","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Singhi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Attri","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jayashree","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"11","article-title":"Vitamin D and diabetes mellitus","volume":"35","author":"Danescu LG","year":"2009","journal-title":"Endocrinology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.04.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.07.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01130.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.015"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0426-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870578"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00589.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06580-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s001250051112","article-title":"Vitamin D supplement in early childhood and risk for type 1 (insulin\u2010dependent) diabetes mellitus","volume":"42","author":"The EURO DIAB sub\u2010study group","year":"1999","journal-title":"Diabetologia"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.6.1128"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.128579"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00439.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(83)90010-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.841324"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110586"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031025"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167177"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80588-0"},{"key":"e_1_2_6_22_1","first-page":"1211","volume-title":"Proc. 8th Workshop on Vitamin D, Paris","author":"Krapf R","year":"1991"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00569.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-00406-7_2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.50.2.142"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0576"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0980"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:06:12Z","timestamp":1696190772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/dme.12200"],"URL":"https:\/\/doi.org\/10.1111\/dme.12200","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]},"assertion":[{"value":"2013-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}