{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:57:13Z","timestamp":1791662233324,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Type\u00a01 diabetes mellitus and coeliac disease are two chronic illnesses associated with each other. Both diseases and their treatments can seriously impair quality of life. The objective of the present study was to investigate health\u2010related quality of life in adult patients diagnosed with both Type\u00a01 diabetes and coeliac disease and compare this with healthy control subjects and control subjects who have Type\u00a01 diabetes only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A generic measure of health\u2010related quality of life (RAND\u201036) and a measure of diabetes\u2010specific quality of life (DQOL) questionnaires were sent to patients diagnosed with both Type\u00a01 diabetes and coeliac disease. The control group consisted of patients with Type\u00a01 diabetes without coeliac disease matched for age, gender and socio\u2010economic status. Generic quality of life scores were compared with data from healthy Dutch control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven patients with Type\u00a01 diabetes and coeliac disease were included and no associations between clinical characteristics and quality of life were observed. Women reported a lower quality of life in social functioning, vitality and mental health than men (all <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). A lower diabetes\u2010specific quality of life was observed regarding diabetes\u2010related worries and social worries in patients with Type\u00a01 diabetes and coeliac disease compared with patients with Type\u00a01 diabetes. Compared with healthy control subjects, quality of life in patients with Type\u00a01 diabetes and coeliac disease was significantly lower, particularly social functioning (Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.76) and general health perception (Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The additional diagnosis of coeliac disease and treatment by gluten\u2010free diet in adult patients with Type\u00a01 diabetes has a considerable, negative impact on quality of life and diabetes\u2010specific quality of life. Women are particularly affected and social functioning and general health perception is compromised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12205","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T16:29:25Z","timestamp":1364401765000},"page":"835-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Compromised quality of life in patients with both Type\u00a01 diabetes mellitus and coeliac disease"],"prefix":"10.1111","volume":"30","author":[{"given":"S. F.","family":"Bakker","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pouwer","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Tushuizen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Hoogma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Groene Hart Hospital Gouda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical Centre Alkmaar Alkmaar"},{"name":"Department of Internal Medicine VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199912)41:4<540::AID-NEU9>3.0.CO;2-P"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2337\/diacare.21.6.909","article-title":"Personal and family factors associated with quality of life in adolescents with diabetes","volume":"21","author":"Grey M","year":"1998","journal-title":"Diabetes Care"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-7560(199905\/06)15:3<205::AID-DMRR29>3.0.CO;2-O"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.11.38"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-040210-092915"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-s011"},{"key":"e_1_2_6_8_1","volume-title":"Het meten van de algemene gezondheidstoestand met de RAND\u201036: een handleiding (Measurement of general health by RAND\u201036: an instruction manual)","author":"Zee KI","year":"1993"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6846.160"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.9.725"},{"key":"e_1_2_6_12_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00785.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2012.01236.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02682.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339909788166828"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03942.x"},{"key":"e_1_2_6_18_1","first-page":"241","article-title":"Quality of life in coeliac disease is determined by perceived degree of difficulty adhering to a gluten\u2010free diet, not the level of dietary adherence ultimately achieved","volume":"20","author":"Barratt SM","year":"2011","journal-title":"J Gastrointestin Liver Dis"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:07:35Z","timestamp":1696190855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/dme.12205"],"URL":"https:\/\/doi.org\/10.1111\/dme.12205","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]},"assertion":[{"value":"2012-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}