{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:40:35Z","timestamp":1776109235832,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>While there is thought to be an association between glucose and lipid metabolism, it is largely unknown whether apolipoprotein\u00a0B and non\u2010high density lipoprotein (HDL) cholesterol are associated with the development of Type\u00a02 diabetes. It is also unknown whether these atherogenic dyslipidaemic profiles have a stronger association with diabetes risk compared with conventional lipid measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 118\u00a0429 subjects without diabetes (70\u00a0980 men and 47\u00a0449 women), aged 17\u201390\u00a0years (mean age 39.6\u00a0years), were enrolled in this study and followed for a mean duration of 3.1\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apolipoprotein\u00a0B and non\u2010HDL cholesterol levels showed a strong association with the development of Type\u00a02 diabetes compared with conventional lipid measurements and their ratios [hazard ratio per 1\u00a0<jats:sc>sd<\/jats:sc>; 1.39 (95%\u00a0CI 1.37\u20131.42) and 1.38 (95%\u00a0CI 1.35\u20131.40), respectively; both <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001]. The Kaplan\u2013Meier survival curve demonstrated that Type\u00a02 diabetes developed more frequently as apolipoprotein\u00a0B or non\u2010HDL cholesterol levels increased across quartiles (both <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). In multivariate Cox regression analyses, both apolipoprotein\u00a0B and non\u2010HDL cholesterol were associated with the development of Type\u00a02 diabetes, independent of other risk factor including age, sex, waist circumference, family history of diabetes, fasting serum glucose and insulin levels, HbA<jats:sub>1c<\/jats:sub>, systolic blood pressure and other conventional lipid measurements [hazard ratio per 1\u00a0<jats:sc>sd<\/jats:sc>; 1.14 (95%\u00a0CI 1.11\u20131.18) and 1.13 (95%\u00a0CI 1.10\u20131.16), respectively; both <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atherogenic dyslipidaemia was more strongly associated with the development of Type\u00a02 diabetes than conventional lipid measurements, and this effect was independent of other well\u2010established risk factor for diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12278","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T16:18:45Z","timestamp":1372781925000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Atherogenic dyslipidaemic profiles associated with the development of Type\u00a02 diabetes: a 3.1\u2010year longitudinal study"],"prefix":"10.1111","volume":"31","author":[{"given":"Y.\u2010C.","family":"Hwang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Medicine Kyung Hee University School of Medicine Kyung Hee University Hospital at Gangdong Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010Y.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Statistics Dongguk University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Hallym University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010W.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.3.173"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.4.369"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2011.35.2.101"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-011-0219-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12663-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.713438"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07098-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01644.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1210\/jcem.85.9.6773","article-title":"Risk for diabetes mellitus in middle\u2010aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. 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