{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:27:15Z","timestamp":1776684435384,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>It is proposed that diabetic neuropathy may affect peripheral bone. Direct innervation of bone as well as neural control over its vascular supply and muscular influences may be affected by diabetes\u2010induced peripheral neuropathies. Associated changes to bone may contribute to the occurrence of foot bone pathology in this population. This systematic review aims to examine the literature related to the effect of diabetic neuropathy on foot bones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods <\/jats:title><jats:p>Studies examining relationships between neuropathy and indicators of bone health (e.g. bone mineral density) in populations with diabetes were sought. Relevant publications were obtained from searches in <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CINAHL<\/jats:styled-content> and Embase in the period up to March 2013. Meta\u2010analysis was performed using a random effects model in the statistical package Stata version\u00a012.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies met the inclusion criteria and were included in the narrative synthesis. All studies were cross\u2010sectional or case\u2013control in design. Four of the 10 included studies found results indicating poorer bone health in those with diabetes and neuropathy compared with those with diabetes without neuropathy. Seven of the 10 studies were able to be included in a meta\u2010analysis. The mean pooled effect was \u20130.36 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20130.76 to 0.04; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08), indicating a non\u2010significant trend towards poorer bone health in those with diabetic neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We did not find a significant relationship between presence of neuropathy in those with diabetes and poorer peripheral bone health. However, methodological limitations of the included studies mean further research is required to investigate this theoretical relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12347","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T22:27:19Z","timestamp":1382567239000},"page":"136-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of diabetic neuropathy on foot bones: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"A. L.","family":"Barwick","sequence":"first","affiliation":[{"name":"School of Health Sciences Faculty of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. A. K. 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