{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:55:33Z","timestamp":1771487733271,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Aims<\/jats:title>To examine the association between changes in procoagulants (fibrinogen factors VII<\/jats:styled-content> and VIII<\/jats:styled-content> and von Willebrand factor) and the risk of insulin resistance.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using data from the Coronary Artery Risk Development in Young Adults study, we followed 2398 black and white adults without diabetes, aged 25\u201337\u00a0years at year\u00a07, to year\u00a020. Levels of fibrinogen factors VII<\/jats:styled-content> and VIII<\/jats:styled-content> and von Willebrand factor were divided in tertiles (low\/middle\/high) at years\u00a07 and 20 and four groups reflecting changes were defined: \u2018low\u2019 (low at years\u00a07 and 20), \u2018stable\u2019 (low\/middle at years\u00a07 and 20, but not both low at years\u00a07 and 20), \u2018high\u2019 (high at year\u00a07 and low\/middle at year\u00a020; or low\/middle at year\u00a07 and high at year\u00a020) and \u2018highest\u2019 (high at years\u00a07 and 20). Linear regression models were used to evaluate 13\u2010year changes (year\u00a020\u2013year\u00a07) in fibrinogen level and factors VII<\/jats:styled-content>, VIII<\/jats:styled-content> and von Willebrand change groups in relation to insulin resistance measures.<\/jats:p><\/jats:sec>Results<\/jats:title>Homeostasis model assessment of insulin resistance (year\u00a020) and changes in log homeostasis model assessment of insulin resistance (year\u00a020\u2013year\u00a07) were significantly associated with the 13\u2010year increase in fibrinogen (P<\/jats:italic>\u00a0<\u00a00.001). Compared with participants in the low group, those in the high group had significantly higher levels of homeostasis model assessment of insulin resistance (year\u00a020) and changes in homeostasis model assessment of insulin resistance (year\u00a020\u2013year\u00a07) for fibrinogen factor VII<\/jats:styled-content> and von Willebrand factor (P<\/jats:italic>\u00a0<\u00a00.017). No significant associations were observed between fibrinogen VIII<\/jats:styled-content> and insulin resistance measures.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>An increase in fibrinogen level and persistently high levels of factor VII<\/jats:styled-content> and von Willebrand factor are significantly associated with increased risk of insulin resistance. These findings provide new insight into the mechanisms to explain the heightened risk for thrombosis in adults with insulin resistance\/diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12387","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T17:51:20Z","timestamp":1387302680000},"page":"462-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in procoagulants track longitudinally with insulin resistance: findings from the Coronary Artery Risk Development in Young Adults (CARDIA<\/scp>) study"],"prefix":"10.1111","volume":"31","author":[{"given":"O. L.","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Okwuosa","sequence":"additional","affiliation":[{"name":"Section of Cardiology Department of Medicine Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Kanaya","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04707.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01046-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.42"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.10.2384"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1486-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.767"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2171"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(92)90098-B"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12387","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T03:36:03Z","timestamp":1696217763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,17]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/dme.12387"],"URL":"https:\/\/doi.org\/10.1111\/dme.12387","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,17]]},"assertion":[{"value":"2013-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}