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Human cohorts and animal models provide compelling data suggesting the role of the one\u2010carbon cycle in modulating the risk of diabetes and adiposity via developmental programming. Early mechanistic studies in animals suggest that alterations to the cellular provision of methyl groups (via the one\u2010carbon cycle) in early developmental life may disrupt <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation and induce future adverse phenotypic changes. Furthermore, replacement of micronutrient deficits at suitable developmental stages may modulate this risk. Current human studies are limited by a range of factors, including the accuracy and availability of methods to measure nutritional components in the one\u2010carbon cycle, and whether its disruptions exert tissue\u2010specific effects. A greater understanding of the causal and mechanistic role of the one\u2010carbon cycle is hoped to generate substantial insights into its role in the developmental origins of complex metabolic diseases and the potential of targeted and population\u2010wide prevention strategies.<\/jats:p>","DOI":"10.1111\/dme.12390","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T17:51:23Z","timestamp":1387302683000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["The role of the one\u2010carbon cycle in the developmental origins of Type\u00a02 diabetes and obesity"],"prefix":"10.1111","volume":"31","author":[{"given":"S.","family":"Finer","sequence":"first","affiliation":[{"name":"University of Cambridge Metabolic Research Laboratories Wellcome Trust\u2010MRC Institute of Metabolic Science Addenbrooke's Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick Coventry &amp; George Eliot Hospital Nuneaton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hitman","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry Queen Mary University of London London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yajnik","sequence":"additional","affiliation":[{"name":"Kamalnayan Bajaj Diabetology Research Centre King Edward Memorial Hospital Research Centre Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11584.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6809.1019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6918.1519"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.07.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07244-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0385"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7119.1342"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707258104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0793-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.232"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp428"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.02.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602383"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.189"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90650-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"National Institute for Health and Clinical Excellence.Diabetes in Pregnancy: Management of Diabetes and its Complications from Pre\u2010Conception to the Post\u2010Natal Period. 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