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Med."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To summarize and critically evaluate the effectiveness of psychological and pharmacological interventions for depression in patients with both diabetes and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized controlled trials investigating psychological and pharmacological interventions for depression in adults with diabetes and depression were included. A comprehensive search of primary studies according to Cochrane were conducted. Primary outcomes were depression and glycaemic control. Further, treatment adherence, diabetes complications, mortality, healthcare costs and quality of life were investigated. Two reviewers identified primary studies and extracted data independently. Random\u2010effects model meta\u2010analyses were conducted to compute overall estimates of treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The database search resulted in 3963 references, of which 19 trials were included. Randomized controlled trials of psychological interventions showed positive effects on short\u2010 and medium\u2010term depression severity [standardized mean difference short\u2010term range \u20131.47; \u20130.14, <jats:italic>n<\/jats:italic>\u00a0=\u00a07; medium\u2010term standardized mean difference \u20130.42 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20130.70 to \u20130.14), <jats:italic>n<\/jats:italic>\u00a0=\u00a03] and depression remission [odds ratio short term 2.88 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.58\u20135.25), <jats:italic>n<\/jats:italic>\u00a0=\u00a04; odds ratio medium term 2.49 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.44\u20134.32), <jats:italic>n<\/jats:italic>\u00a0=\u00a02]. Effects on glycaemic control in psychological intervention trials varied substantially (standardized mean difference range \u20130.97 to 0.47, <jats:italic>n<\/jats:italic>\u00a0=\u00a04). Selective serotonin reuptake inhibitors showed a moderate beneficial effect on short\u2010term depression severity [standardized mean difference \u20130.39 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20130.64 to \u20130.13], <jats:italic>n<\/jats:italic>\u00a0=\u00a05) and depression remission [odds ratio 2.52 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.11\u20135.75), <jats:italic>n<\/jats:italic>\u00a0=\u00a02]. Glycaemic control improved in randomized controlled trials comparing selective serotonin reuptake inhibitors with placebo at the end of treatment [standardized mean difference \u20130.38 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20130.64 to \u20130.12), <jats:italic>n<\/jats:italic>\u00a0=\u00a05].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psychological and pharmacological interventions positively affect depression outcomes in patients with diabetes at the end of treatment. Furthermore, short\u2010term glycaemic control improved moderately in pharmacological trials. Most outcomes have not been investigated sufficiently. Moreover, there is a lack of follow\u2010up data for pharmacological trials limiting the evidence on the sustainability of treatment effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12452","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T12:38:54Z","timestamp":1395837534000},"page":"773-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Psychological and pharmacological interventions for depression in patients with diabetes mellitus: an abridged Cochrane review"],"prefix":"10.1111","volume":"31","author":[{"given":"H.","family":"Baumeister","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Psychology and Psychotherapy Institute of Psychology University of Freiburg"},{"name":"Medical Psychology and Medical Sociology University of Freiburg Medical Faculty Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hutter","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Psychology and Psychotherapy Institute of Psychology University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bengel","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Psychology and Psychotherapy Institute of Psychology University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01943.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1069"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01814.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.08.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.06.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(12)70004-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0985"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.7.934"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.21.3278"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0158"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200107000-00015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.11.2668"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.176"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.464"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2008.09.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1873-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(12)70008-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.03.011"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323404"},{"key":"e_1_2_9_22_1","first-page":"CD008381","article-title":"Psychological and pharmacological interventions for depression in patients with diabetes mellitus and depression","volume":"12","author":"Baumeister H","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_23_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioral Disorders. 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