{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:24:39Z","timestamp":1790040279545,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our aim was to assess the number of medications prescribed to people with Type\u00a01 or Type\u00a02 diabetes mellitus and to compare these to recommendations by guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Data from 155 and 154 people with Type\u00a01 and Type\u00a02 diabetes, respectively, were analysed. Prescribed medications (glucose\u2010lowering drugs, blood pressure medications, drugs to treat cardiovascular risk or diseases, etc.) were counted as compounds per day, tablets per day, injections per day, or other modes of administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>People with Type\u00a02 diabetes were prescribed 8.4\u00a0\u00b1\u00a03.0 different drug compounds per day (maximum, 16), 8.6\u00a0\u00b1\u00a03.9 tablets per day (maximum, 22), 2.6\u00a0\u00b1\u00a01.6 injections per day (maximum, 7), in total 11.6\u00a0\u00b1\u00a04.5 doses of any medication per day (maximum, 27). The numbers for people with Type\u00a01 diabetes were 5.5\u00a0\u00b1\u00a03.4 compounds per day (maximum, 15), 4.5\u00a0\u00b1\u00a04.3 tablets per day (maximum, 18), 3.9\u00a0\u00b1\u00a02.2 injections per day (maximum, 8), in total 8.5\u00a0\u00b1\u00a05.1 doses of any medication per day (maximum, 22). Over 97% of the prescriptions corresponded to recommendations by guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The number of prescribed drugs is high in people with diabetes mellitus, and higher for those with Type\u00a02 than with Type\u00a01 diabetes. The compatibility of prescriptions with guideline recommendations suggests that even this high number of prescriptions will provide a clinical benefit. The current analysis could provide a basis for a realistic judgement of the burden imposed by polypharmacy in people with diabetes mellitus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12497","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T16:41:08Z","timestamp":1399999268000},"page":"1078-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Polypharmacy in people with Type\u00a01 and Type\u00a02 diabetes is justified by current guidelines\u2014a comprehensive assessment of drug prescriptions in patients needing inpatient treatment for diabetes\u2010associated problems"],"prefix":"10.1111","volume":"31","author":[{"given":"S.","family":"Bauer","sequence":"first","affiliation":[{"name":"Diabeteszentrum Bad Lauterberg Bad Lauterberg im Harz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Nauck","sequence":"additional","affiliation":[{"name":"Diabeteszentrum Bad Lauterberg Bad Lauterberg im Harz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr077"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2007.12.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100347"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1218"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1408"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"e_1_2_7_9_1","volume-title":"S3\u2010Leitlinie Therapie des Typ\u20101\u2010Diabetes (S3\u2010Guideline for Therapy of Type 1 Diabetes)","author":"B\u00f6hm BO","year":"2011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098798"},{"key":"e_1_2_7_11_1","unstructured":""},{"key":"e_1_2_7_12_1","unstructured":"Kassen\u00e4rztliche Bundesvereinigung (KBV) and Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) Nationale Versorgungs Leitlinie Chronische KHK \u2010 Kurzfassung 2013"},{"key":"e_1_2_7_13_1","unstructured":"Kassen\u00e4rztliche Bundesvereinigung (KBV) and Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) Nationale Versorgungsleitlinie Herzinsuffizienz \u2010 Kurzfassung 2013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1300\/J027v24n01_07"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050445"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0977-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.11.1636"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.10.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.2.170"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401063300103"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.829176"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1533"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80109-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00689.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.10.1512"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-009-9202-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.01.019"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.12.2800"},{"key":"e_1_2_7_29_1","first-page":"71","article-title":"Oral antidiabetic medication adherence and glycemic control in managed care","volume":"14","author":"Rozenfeld Y","year":"2008","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38875.675486.55"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03000.x"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:26:44Z","timestamp":1696224404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,11]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/dme.12497"],"URL":"https:\/\/doi.org\/10.1111\/dme.12497","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,11]]},"assertion":[{"value":"2013-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}