{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:27:03Z","timestamp":1773142023258,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse the effects of thyroid hormones on \u03b2\u2010cell function and glucose metabolism in people with prediabetes who are euthyroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 111 people who were euthyroid underwent 75\u2010g oral glucose tolerance tests, of whom 52 were assigned to the normal glucose tolerance and 59 to the prediabetes groups. Homeostatic model assessment of \u03b2\u2010cell function, insulinogenic index and areas under the curve for insulin and glucose were evaluated as indices of pancreatic \u03b2\u2010cell function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both groups, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, fasting insulin, homeostasis model assessment ratio and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol correlated significantly with all indices of pancreatic \u03b2\u2010cell function. Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group. Multiple linear regression analysis showed that free triiodothyronine was an independent variable that had a positive correlation with all indices of \u03b2\u2010cell function in the prediabetes group. By contrast, no such correlation was found in the normal glucose tolerance group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Free triiodothyronine is associated with both basal and glucose\u2010stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12589","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T06:29:37Z","timestamp":1411712977000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Positive association of free triiodothyronine with pancreatic \u03b2\u2010cell function in people with prediabetes"],"prefix":"10.1111","volume":"32","author":[{"given":"T.","family":"Oda","sequence":"first","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Taneichi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Togashi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hangai","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Matsui","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sasai","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Honma","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Takebe","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolism Department of Internal Medicine Iwate Medical University Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2007.S154"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.5.E788"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17645"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-1-62"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-5-1038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20460"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20293"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06110"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-186841"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01056.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.02166"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0849"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.224.173"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917120-00009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0592"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00365-5"},{"key":"e_1_2_8_19_1","volume-title":"Report of a WHO_IDF Consultation","author":"World Health Organization DaDoDMaIH","year":"2006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.9.3752-3762.2005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/8751"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18555"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.7.1107"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.100222"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3330471"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.1.69"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803248"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903136688"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.868"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.11.024"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.06.010"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12589","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:09:44Z","timestamp":1696345784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,18]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/dme.12589"],"URL":"https:\/\/doi.org\/10.1111\/dme.12589","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,18]]},"assertion":[{"value":"2014-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}