{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:58:01Z","timestamp":1771509481094,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jeppe Juhls Mindelegat"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recruitment of brown adipose tissue is a promising strategy to treat obesity and Type 2 diabetes, but the physiological effects of a large amount of metabolically active brown adipose tissue in humans are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>In the present paper, we report a case of massive brown adipose tissue infiltration of the visceral adipose tissue depot in a person with Type 2 diabetes with a catecholamine\u2010secreting paraganglioma. The patient was evaluated with [18F]\u2010fludeoxyglucose positron emission tomography\/computed tomography on three occasions: pre\u2010therapy, during \u03b1\u2010blockade and postoperatively. During surgery, biopsies of visceral and subcutaneous adipose tissue were obtained and evaluated for brown adipose tissue. At diagnosis, brown adipose tissue glucose uptake, assessed by [18F]\u2010fludeoxyglucose\u2010positron emission tomography, was massively increased. [18F]\u2010fludeoxyglucose uptake was confined to known locations for brown adipose tissue, with additional uptake in the visceral adipose tissue. As a result of increased thermogenesis, resting energy expenditure was doubled. After surgical removal of the tumour, antidiabetic medicine was no longer needed, despite an 8.2\u2010kg weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results show that human visceral adipose tissue holds an unprecedented potential for brown adipogenic differentiation; however, a detrimental effect on glucose metabolism persisted despite massive brown adipose tissue activity, with a doubling of resting energy expenditure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12595","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T10:08:16Z","timestamp":1412071696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue"],"prefix":"10.1111","volume":"32","author":[{"given":"E.","family":"S\u00f8ndergaard","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"The Danish Diabetes Academy Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and positron emission tomography Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and positron emission tomography Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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