{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:17:00Z","timestamp":1791267420921,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck, Sharp and Dohme","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the effects of the dipeptidyl peptidase\u20104 inhibitor sitagliptin on blood pressure and heart rate, measured during a previously reported study, in which the effects of sitagliptin during intraduodenal glucose infusion at the rate of 2\u00a0kcal\/min on glucose homeostasis were examined in patients with Type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 10 people with Type 2 diabetes were studied on two different days, 30\u00a0min after oral ingestion of sitagliptin (100\u00a0mg) or placebo. Intraduodenal glucose was infused at 2\u00a0kcal\/min (60\u00a0g over 120\u00a0min), and blood pressure, heart rate, plasma glucagon\u2010like peptide\u20101 and glucose\u2010dependent insulinotropic polypeptide (total and intact), glucose, insulin and glucagon responses were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In response to intraduodenal glucose infusion, heart rate (treatment effect: <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and serum insulin concentration (treatment \u00d7 time interaction: <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.041) were higher after sitagliptin treatment than placebo, without a significant difference in blood pressure, plasma glucagon or glucose. During intraduodenal glucose infusion, there was a substantial increase in plasma total glucose\u2010dependent insulinotropic polypeptide on both days (time effect: <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), but not in total glucagon\u2010like peptide\u20101. After sitagliptin, plasma intact glucagon\u2010like peptide\u20101 concentration increased slightly (treatment\u00a0\u00d7\u00a0time interaction: <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.044) and glucose\u2010dependent insulinotropic polypeptide concentration increased substantially (treatment \u00d7 time interaction: <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003).The heart rate response to intraduodenal glucose was related directly to plasma intact glucose\u2010dependent insulinotropic polypeptide concentrations (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.75, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sitagliptin increased the heart rate response to intraduodenal glucose infusion at 2\u00a0kcal\/min in people with Type 2 diabetes, which was associated with augmentation of plasma intact glucose\u2010dependent insulinotropic polypeptide concentrations. These observations warrant further clarification of a potential role for glucose\u2010dependent insulinotropic polypeptide in the control of the \u2018gut\u2013heart\u2019 axis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12622","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T14:59:14Z","timestamp":1414853954000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose\u2010dependent insulinotropic polypeptide?"],"prefix":"10.1111","volume":"32","author":[{"given":"T.","family":"Wu","sequence":"first","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. G.","family":"Trahair","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Bound","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Deacon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016106776359826"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.183"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80232-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110270"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2583"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03496.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1627"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6346.916"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021873"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0266"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6977.446"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509091657"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00031-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-158-40222"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1451"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.30.3.219"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.191866"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519609088805"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60307-8"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12622","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:36:23Z","timestamp":1696253783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,11]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/dme.12622"],"URL":"https:\/\/doi.org\/10.1111\/dme.12622","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,11]]},"assertion":[{"value":"2014-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}