{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:16:36Z","timestamp":1768875396625,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novo Nordisk Regional Diabetes Support Scheme grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the prevalence, clinical significance and antepartum to postpartum trajectory of zinc transporter 8 autoantibodies, a novel marker of islet autoimmunity, in women with gestational diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 302 consecutive women attending a multi\u2010ethnic Australian gestational diabetes clinic were prospectively studied. Zinc transporter 8 autoantibodies were measured at gestational diabetes diagnosis and 3\u00a0months postpartum using an enzyme\u2010linked immunosorbent assay, and were correlated with maternal phenotype, antepartum and postpartum glucose tolerance, treatment and perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 302 women, 30 (9.9%) were positive for one islet autoantibody antepartum. No participant had multiple islet autoantibodies. Zinc transporter 8 autoantibodies were the most prevalent autoantibody [zinc transporter 8 autoantibodies: 13\/271 women (4.8%); glutamic acid decarboxylase 7\/302 women (2.3%); insulinoma\u2010associated antigen\u20102: 6\/302 women (2.0%); insulin: 4\/302 women (1.3%)]. Zinc transporter 8 autoantibody positivity was associated with a higher fasting glucose level on the antepartum oral glucose tolerance test, but not with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, insulin use, perinatal outcomes or postpartum glucose intolerance. Five of the six women who tested positive for zinc transporter 8 autoantibodies antepartum were negative for zinc transporter 8 autoantibodies postpartum, which corresponded to a significant decline in titre antepartum to postpartum (26.5 to 3.8 U\/ml; <jats:italic>P<\/jats:italic>=0.03). This was in contrast to the antepartum to postpartum trajectory of the other islet autoantibodies, which remained unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zinc transporter 8 autoantibodies were the most common islet autoantibody in gestational diabetes. Zinc transporter 8 autoantibody positivity was associated with slightly higher fasting glucose levels and, unlike other islet autoantibodies, titres declined postpartum. Zinc transporter 8 autoantibodies may be a marker for islet autoimmunity in a proportion of women with gestational diabetes, but the clinical relevance of zinc transporter 8 autoantibodies in pregnancy and gestational diabetes requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12629","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T13:04:01Z","timestamp":1415711041000},"page":"359-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Zinc transporter 8 autoantibodies: what is their clinical relevance in gestational diabetes?"],"prefix":"10.1111","volume":"32","author":[{"given":"V. L.","family":"Rudland","sequence":"first","affiliation":[{"name":"Discipline of Medicine The University of Sydney Sydney Australia"},{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"},{"name":"Department of Endocrinology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pech","sequence":"additional","affiliation":[{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Harding","sequence":"additional","affiliation":[{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Endocrinology Laboratory Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Endocrinology Laboratory Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Molyneaux","sequence":"additional","affiliation":[{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Yue","sequence":"additional","affiliation":[{"name":"Discipline of Medicine The University of Sydney Sydney Australia"},{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"},{"name":"Department of Endocrinology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Discipline of Medicine The University of Sydney Sydney Australia"},{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"},{"name":"Department of Endocrinology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Ross","sequence":"additional","affiliation":[{"name":"Discipline of Medicine The University of Sydney Sydney Australia"},{"name":"Diabetes Centre Royal Prince Alfred Hospital Sydney Australia"},{"name":"Department of Endocrinology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-s204"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0157"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-24"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.963"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.03.06.db05-0746"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.06.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00721.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.03.06.dc05-1118"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000232"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ12-0069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003815"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0071"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05616"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1165-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705894104"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2081"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03766.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb140192.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90349-0"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"S1","article-title":"American Diabetes Association Clinical Practice Recommendations 2001","volume":"24","year":"2001","journal-title":"Diabetes Care"},{"key":"e_1_2_9_22_1","first-page":"525","article-title":"ACOG Practice Bulletin. Clinical management guidelines for obstetrician\u2010gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes","volume":"98","author":"American College of Obstetricians Gynecologists Committee on Practice","year":"2001","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199608)13:8<748::AID-DIA164>3.0.CO;2-I"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01925.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0813"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.1.197"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007658"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-010-0110-x"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:11:59Z","timestamp":1696306319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,28]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/dme.12629"],"URL":"https:\/\/doi.org\/10.1111\/dme.12629","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,28]]},"assertion":[{"value":"2014-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}