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Med."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the association between depression and impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in middle\u2010aged and elderly Chinese people, and whether depression was associated with different treatment regimens or durations of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed among 229\u00a0047 adults living in the community aged \u2265\u00a040\u00a0years from 25 centres in China. The self\u2010reported depression rating scale Patient Health Questionnaire\u00a09 (<jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u20139) was used to diagnose probable and sub\u2010threshold depression. Glucose metabolism status was determined according to World Health Organization 1999 diagnostic criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The numbers of participants with normal glucose regulation, impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes were 120\u00a0458, 59\u00a0512, 24\u00a0826 and 24\u00a0251, respectively. The prevalence of sub\u2010threshold depression in the total sample of participants was 4.8% (4.8%, 4.8%, 4.4% and 5.6% from normal glucose regulation to previously diagnosed diabetes, respectively), and the prevalence of probable depression was 1.1% (1.1%, 1.0%, 0.9% and 1.8% from normal glucose regulation to previously diagnosed diabetes, respectively). Compared with participants with normal glucose regulation, those with previously diagnosed diabetes had increased odds of probable depression [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a01.61, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.39\u20131.87] and sub\u2010threshold depression (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.14, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.06\u20131.24), after adjustment for multiple confounding factors. Newly diagnosed diabetes or impaired glucose regulation was not associated with depression. Among those with previously diagnosed diabetes, insulin treatment was associated with greater odds of depression compared with no treatment or oral anti\u2010diabetic medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previously diagnosed diabetes, but not newly diagnosed diabetes or impaired glucose regulation, was associated with a higher prevalence of depression. Patients receiving insulin were more likely to have depression than those not receiving treatment or being treated with oral anti\u2010diabetic medicine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12649","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T13:39:41Z","timestamp":1417268381000},"page":"935-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults"],"prefix":"10.1111","volume":"32","author":[{"given":"J. C.","family":"Sun","sequence":"first","affiliation":[{"name":"Laboratory of Endocrine and Metabolic Diseases Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. F.","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. M.","family":"Mu","sequence":"additional","affiliation":[{"name":"People's Liberation Army General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Xiehe Hospital Huazhong University of Science and Technology School of Medicine Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. X.","family":"Shi","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guiyang Medical College Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affilliated Hospital of Haerbin Medical University Haerbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University Jiangsu Province Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Yan","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Wan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Luzhou Medical College Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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